慢性肺原性心脏病患者血浆内皮素-1水平及其临床意义  

Clinical significance of changes of plasma endothelin1 levels in patients with chronic cor pulmonale

作　　者：李天木[1,2] 马中富[1,2] 蒋祖勋[1,2] 徐钟源[1,2] 关开泮[1,2] 

机构地区：[1]中山医科大学附一院急诊科 [2]广东省人民医院心血管病研究所

出　　处：《中国危重病急救医学》1997年第1期22-23,共2页Chinese Critical Care Medicine

摘　　要：目的：探讨内皮素１（ＥＴ１在慢性肺原性心脏病（肺心病）发病过程中的作用及其临床意义。方法：采用放射免疫分析法测２５例健康者和４２例慢性肺心病患者治疗前后的血浆ＥＴ１含量，并与动脉血气分析及血清肌酐浓度作相关分析。结果：肺心病患者ＥＴ１水平较对照组显著升高（８７．１０±２７．９７ｎｇ／Ｌ比５８．７０±１１．６２ｎｇ／Ｌ，Ｐ＜０．０１）；治疗后ＥＴ１水平显著下降（７０．９０±１６．７５ｎｇ／Ｌ）与治疗前比较，Ｐ＜０．０１，但仍高于正常对照组（Ｐ＜０．０１）；且血浆ＥＴ１含量与ＰａＯ２和ｐＨ值呈显著负相关（ｒ分别为０．７３９和０．４７６），与ＰａＣＯ２和血清肌酐浓度呈显著正相关（ｒ分别为０．４５７和０．３９７）。结论：血浆ＥＴ１在肺心病的发病中可能起一定作用；测定ＥＴ１水平有助于判断病情变化及预后。Objective:To investigate the role of endothelin1(ET1) in the pathogenesis of cor pulmonale and its clinical significance.Methods:Plasma endothelin1(ET1) level was measured by radioimmunoassay(RIA) in 42 patients with chronic cor pulmonale before and after treatment and in 25 healthy volunteers.Correlation was analyzed between the results and the levels of arterial blood gases and serum creatinine.Results:ET1 level was significantly higher in cor pulmonale patients(87 10±27 97ng/L vs 58 70±11 62ng/L, P <0 01) and decreased significantly after treatment (70 90±16 75ng/L, P <0 01),but was still higher than that in the controls( P <0 01).There was a significant negative correlation between ET1 level and PaO 2 and PH values( r =0 739 and 0 476 respectively).A significant positive correlation was found between ET1 level and levels of PaCO 2 and serum creatinine( r =0 457 and 0 397 respectively).Conclusions:ET1 may play an important role in the pathophysiological process of chronic cor pulmonale,and determination of ET1 level may help judge the change of the patient′s condition and the prognosis.

关 键 词：内皮素 肺心病 放射免疫分析 

分 类 号：R541.5[医药卫生—心血管疾病]