脑脉舒宁对大鼠主动脉条收缩的影响  

Effects of Naomaishuning of isolated rat aortic strips in-duced calcium norepinephrine and potassium

作　　者：王淑英 李艳 路西明 王建刚 王学廷 王建业 徐小霞 

出　　处：《洛阳医专学报》1997年第1期24-26,共3页Journal of Luoyang Medical College

摘　　要：用大鼠胸主动脉条测定脑脉舒宁对去甲肾上腺素、氯化钙的量效曲线，以及对单剂量氯化钾所致收缩的影响。结果表明：脑脉舒宁能使去甲肾上腺素、氯化钙的量效曲线右移，最大反应压低，呈非竞争性拮抗。同时也可抑制高钾去极化引起的血管条收缩．The effect of Naomaishuning on rat aortic strips was examined. The results showed that Naomaishuning shifted the cumulative concentration-response curves for CaCl2(0. 03~3. 0mmol/L) and norepinephrine (3 × 10^(-7) ~ 3 × 10^(-3)) to right, and depressed their maximal re-sponses. It appeared that the Naomaishuning was noncompetitive antagonist to CaCl2 and norepinephrine. Naomaishuning also inhibited the contration of aortic strips evoked by single dose of KCl. The results suggested that Naomaishuning block calcium channels.

关 键 词：主动脉条 脑脉舒宁 中药品 药理学 

分 类 号：R286[医药卫生—中药学] R285.5[医药卫生—中医学]