肾脏损伤时有机阴离子转运子表达变化及其意义  

Altered expression of organic anion transporters and its significance in kidney disease states

作　　者：伍军[1] 阳晓[1] 余学清[1] 

机构地区：[1]中山大学附属第一医院肾内科,广东广州510080

出　　处：《国际内科学杂志》2007年第8期493-496,F0003,共5页International Journal of Internal Medicine

基　　金：国家自然科学基金(30271668;30572290)

摘　　要：有机阴离子转运子(OAT)在机体清除各种内、外源性有机阴离子的过程中发挥极其重要的作用。在肾脏,OAT参与排泄许多外源性有机阴离子,如药物、环境中的化学物质、生物毒素以及许多内源性有机阴离子包括多种尿毒症毒素等。近年研究发现,各种肾脏疾病条件下OAT表达发生变化,并由此而产生相应病理生理效应。本文讨论了OAT在近端肾小管上皮细胞的生物学特征、肾脏病变状态下的表达变化及其病理生理学意义。Organic anion transporters （OATs） play a critical role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many exogenous organic anions such as drugs, numerous environmental chemicals, biological toxin and endogenous organic anions including many kinds of uremic toxin, Recently, several studies have indicated that the expressions of OATs are affected in various kidney diseases and cause consequent pathophysiolgical effects. In this review, current knowledge and recent progress in the understanding of OATs＇ biological characteristics in renal proximal tubular and its＇ expression change and significance in disease states are discussed.

关 键 词：有机阴离子转运子 肾脏 排泄 

分 类 号：R692[医药卫生—泌尿科学]