血浆置换联合血浆灌流治疗急性妊娠脂肪肝疗效评价  

The therapeutic effect of plasma exchange and plasma perfusion on acute fatty liver of pregnancy.

作　　者：郭莲怡[1] 闻颖[1] 刘沛[1] 

机构地区：[1]中国医科大学盛京医院传染科

出　　处：《中国实用内科杂志》2007年第5期371-372,375,共3页Chinese Journal of Practical Internal Medicine

基　　金：卫生部临床重点项目<重型肝炎抢救新技术研究>(97100252)

摘　　要：目的评价血浆置换(PE)联合血浆灌流(PP)在急性妊娠脂肪肝治疗中的作用及安全性。方法将中国医科大学盛京医院传染科2000—2005年21例妊娠急性脂肪肝住院患者分为2组,对照组(9例)予内科保守治疗,治疗组(12例)在内科保守治疗的同时,应用PE联合PP。观察患者的症状、体征、治疗前及治疗4周、6周后的肝、肾功能和凝血酶原活动度的变化,以及PE联合PP治疗的不良反应。结果治疗组10例患者的症状、体征明显改善,肝、肾功能指标明显好转,有效率为83.33%,与对照组(33.33%)比较差异有显著性意义(P<0.01),且无一例因不良反应而中止治疗。结论PE联合PP治疗急性妊娠脂肪肝安全有效,并发症少,在病程早期连续应用能有效地阻止病情进展。Objective To study the therapeutic effect of plasma exchange and plasma perfusion（ PE ＋ PP）on acute fatty liver of pregnancy. Methods Twenty-one patients with acute fatty liver of pregnancy were divided into two groups. In the treated group,the patients were treated with （PE ＋ PP） on the basis of the conventional therapy, and the control group received the conventional therapy only. Liver function ,kidney function and prothrombin activity（PTA） before treatment and 4 weeks ,6 weeks after treatment were observed. Results After treatment with （PE ＋ PA） ,the liver function,kidney function and PTA were ameliorated at 4 weeks and 6 weeks（P 〈0. 01 ）. The total effective rate in the treated group was 83.33%, while 33.33% in the control group. There were significant differences between the two groups（P 〈0. 01 ）. Conclusion Artificial liver support system can ameliorate the prognosis of acute fatty liver of pregnancy and increase the survival rate. pregnancy

关 键 词：血浆置换 血浆灌流 急性妊娠脂肪肝 

分 类 号：R5[医药卫生—内科学]