苦瓜 黄芪 黄芩苷对2型糖尿病大鼠模型胰岛素抵抗的影响  

Effects of Balsam pear,Astragalus membranaceus and Baicalin on Insulin Resistance in Type 2 Diabetic Rat Model

作　　者：郝玉美[1] 刘洪琪[1] 

机构地区：[1]潍坊学院医院,山东潍坊261061

出　　处：《辽宁中医药大学学报》2007年第5期6-7,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察中药苦瓜、黄芪、黄芩苷实验性2型糖尿病大鼠血糖、胰岛素和胰岛素敏感指数的影响。方法:用高热量饲料加小剂量链脲佐菌素(30mg/kg)建立实验性2型糖尿病大鼠模型后,用苦瓜、黄芪、黄芩苷治疗6周,测定空腹血糖,血清胰岛素,计算出胰岛素敏感指数。结果:苦瓜、黄芪、黄芩苷能降低实验性2型糖尿病大鼠空腹血糖、提高胰岛素敏感指数。结论:苦瓜、黄芪、黄芩苷具有改善实验性2型糖尿病大鼠胰岛素抵抗的作用。Objective： To study the effects of Balsam pear, Astragalus membranaceus, Baicalin on blood sugar, insulin and insulin sensitivity index in type 2 diabetic rat model.Methods ： To build the rat model of type 2 diabetes mellitus by small dose injection of STZ （ 30mg/kg ） and high calorie feeding, and after being treated with Balsam pear, Astragalus membranaceus, Baicalin for 6 weeks, the fasting blood sugar and serum insulin of the experimental rats were measured to be calculated the insulin sensitivity index. Results ： Balsam pear, Astragalus membranaceus, Baicalin reduced the fasting blood sugar and enhanced the insulin sensitivity index. Conclusion ： Balsam pear, Astragalus membranaceus, BaJcalin can relieve insulin resistance of rat model of type 2 diabetes mellitus.

关 键 词：2型糖尿病 胰岛素抵抗 苦瓜 黄芪 黄芩苷 

分 类 号：R285.6[医药卫生—中药学]