GC-MS法测定人工麝香缓释片中麝香酮的含量  

Determination of Muscone in Artificial-Musk Sustained-release Tablets by GC-MS

作　　者：郭波红[1] 程怡[2] 陈文俊 

机构地区：[1]广东药学院药剂教研室,广东广州510006 [2]广州中医药大学中药学院,广东广州510405 [3]广州汉方现代中药研究所,广东广州510400

出　　处：《辽宁中医药大学学报》2007年第5期161-162,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省自然科学基金项目(980638);广州市科技攻关资助(02Z3-E5021)

摘　　要：目的：建立人工麝香缓释片的含量测定方法。方法：选择GC-MS联用仪,DB-1石英毛细管柱（30m×0.25mm）,以高纯度氦气为载气,异补骨脂素为内标物。结果：0.024~0.384mg/mL范围内,进样量与峰面积呈良好的线性关系（r=0.9994）,平均回收率为98.01%,RSD=1.95%（n=6）。结论：方法简便、准确、重现性好,可用于人工麝香缓释片的质量控制。Objective ： To establish a method for the content determination of Artificial-Musk Sustainedrelease Tablets. Methods ： Gas chromatography combined with mass spectrography （ GC-MS ） was used to analyze the content of muscone in a DB-1 capillary column （ 30m × 0.25mm ）, helium gas of high purity was used as the carrier gas and iso-psoralen was used as the internal standard. Results ： There was a good linear relationship between the concentration of gliclazide and the areas in the range of 0.024-0.384 mg/mL （r=0.9994）. The average recovery was 98.01% with RSD of 1.95% （n=6）. Conclusion：This method was simple, accurate and reproducible. It can be used as the quality control for artificial-musk sustained-release tablets.

关 键 词：GC-MS 人工麝香缓释片 含量测定 

分 类 号：R284.1[医药卫生—中药学]