胰泰复方对慢性胰腺炎胰腺纤维化大鼠血清Ⅲ型前胶原氨基端肽含量的影响  

Effect of YITAI Compounded Medication on Contents of Procollagen Ⅲ N-terminal Peptide of the Rats with Chronic Pancreatitis Fibrosis

作　　者：刘华生[1] 林旭红[2] 周景华[3] 

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150040 [2]黑龙江中医药大学,硕士生哈尔滨150040 [3]黑龙江中医药大学附属医院,哈尔滨150040

出　　处：《中国中医急症》2007年第8期971-972,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金资助项目(No.D2005-37)

摘　　要：目的观察中药胰泰复方对慢性胰腺炎胰腺纤维化大鼠血清Ⅲ型前胶原氨基端肽(PⅢNP)含量的影响。方法以精氨酸左下腹腔注射制备大鼠慢性胰腺炎模型,予相应药物灌胃治疗,2个月后取血清用双抗体夹心ABC-ELISA法测定PⅢNP的含量。结果模型组PⅢNP含量明显高于空白组、中药对照组及中药治疗组,中药治疗组PⅢNP含量低于中药对照组。结论胰泰复方能降低血清中PⅢNP的含量,对慢性胰腺炎胰腺纤维化具有恢复作用。Objective： To investigate the influences of YITAI Compounded Medication on the contents of Procollagen Ⅲ N - terminal Peptide（PⅢNP）of the model rats with chronic pancreatitis fibrosis. Methods： To establish the chronic pancreatitis rats model with L -arginine with the method of celiac injection, we gave them Y1 TA1 Compounded Medication and collected serum to check the contents of PⅢNP with the method of double antibody sandwich. Results： The contents of PⅢNP in model group was obviously higher than normal group, Chinese medicine control group and Chinese medicine treatment group, the contents of PⅢNP in Chinese medicine treatment group was lower than Chinese medicine control group. Conclusions： Y1TA1 Compounded Medication can decrease the contents of PⅢNP in serum, so it plays an important role in the recovery of chronic pancreatitis fibrosis.

关 键 词：慢性胰腺炎 胰腺纤维化 胰泰复方 Ⅲ型前胶原氨基端肽 

分 类 号：R285.5[医药卫生—中药学]