牛黄熄风胶囊的抗血小板聚集及促纤溶作用  

THE EFFECTS OF NIUHUANG XIFENG CAPSULE ON AGGREGATION OF PLATELED AND FIBRINOLYSIS

作　　者：唐可欣[1,2] 王凤斌[1,2] 李桂芝 马金栋[1,2] 郎晓东 

机构地区：[1]潍坊医学院生理学教研室 [2]潍坊市人民医院

出　　处：《潍坊医学院学报》1997年第2期84-85,共2页Acta Academiae Medicinae Weifang

基　　金：山东省中医药管理局基金

摘　　要：目的观察牛黄熄风胶囊（ＮＨＸＦＣ）对大鼠体内血小板聚集率及优球蛋白溶解时间的影响。方法将２４只Ｗｉｓｔａｒ大鼠随机分为实验组、药物对照组和生理盐水对照组，分别以牛黄熄风胶囊、脑血康口服液和生理盐水定量灌胃，７ｄ后心脏取血测定其血小板聚集率及优球蛋白溶解时间，并进行组间比较。结果牛黄熄风胶囊组血小板聚集率明显低于脑血康组（Ｐ＜０．０１）和生理盐水对照组（Ｐ＜０．０１），而优球蛋白溶解时间明显短于生理盐水组（Ｐ＜０．０１），但与脑血康组间差异无显著性（Ｐ＞０．０５）。结论牛黄熄风胶囊具有显著的抗血小板聚集及促纤溶作用，其抗血小板聚集作用优于脑血康。Objective To observe the effect of Niuhuang Xifeng capsule(NHXFC) on aggregation of platelet and the time of firinolysis.Method 24 Wistar rats were randomly divided into three groups:The group of NHXFC,Naoxue Kang and normal saline,and were given NHXFC,Naoxue Kang and normal saline for seven days respectively.Result The rate of aggregation of platelet is signifcantly lower in group of NHXFC than in Naoxue Kang (P<0.01) and in normal saline (P<0.01).The time of fibrinolysis is shorter in group of NHXFC than in normal saline (P<0.01).But there is no significant difference between the group of NHXFC and Naoxue Kang (P>0 05).〖WT5HX]Conclusion NHXFC has significant effect on anticoagulation and fibrinolysis.Its anticoaglation effect is better than Naoxue Kang.

关 键 词：牛黄熄风胶囊 血小板聚集率 大鼠 

分 类 号：R285.5[医药卫生—中药学]