山茱萸环烯醚萜总苷对2型糖尿病心脏病变大鼠胰岛素抵抗及血脂含量的影响  

Protecting effect of total iridoid glycoside in Fructus Corni Officinalis on IR and blood lipid level of rats with type 2 diabetic cardiopathy

作　　者：刘洪[1] 许惠琴[1] 时艳[1] 

机构地区：[1]南京中医药大学药学院图书馆,南京210029

出　　处：《中药药理与临床》2007年第3期36-39,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：江苏省中医药局基金项目

摘　　要：目的:观察山茱萸环烯醚萜总苷(ICO)对2型糖尿病心脏病变大鼠胰岛素抵抗及血脂含量的影响。方法:大鼠以高脂饲养结合STZ腹腔注射造模,2周后灌胃给予ICO(0.1,0.2g/kg)或氨基胍(AG,0.1g/kg)治疗,连续16周。检测体重、空腹血糖、血清Ins、Ins-Ab、CHOL、TG、HDL-C及LDL-C含量;分离心脏进行形态学观察。结果:模型组大鼠体重、血糖、Ins-Ab、IR、CHOL、TG、LDL-C明显升高,Ins水平显著降低;光镜检查显示心肌肥大伴程度不等的间质水肿和组织细胞增生,心内膜或心包膜有轻度炎症及纤维化。ICO及AG组大鼠体重、血糖、Ins-Ab、IR、CHOL、TG、LDL-C均明显降低,心肌肥大程度减轻。结论:ICO对2型糖尿病心脏病变有一定的保护作用。Objective：To investigate the protecting effect of total iridoid glycoside in Fructus Corni Officinalis（ICO） on IR and blood lipid level of rats with type 2 diabetic cardiopathy. Method：Models were made with high - fat diet and STZ injection. Two weeks later, ICO （0. 1 , 0. 2 g/kg） and AG（0. 1 g/kg） were used in the treatment for 16 weeks. Result： In the model group , weight,blood sugar,serum Ins- Ab, IR,CHOL,TG and LDL - C of the rats increased , the levels of serum Ins decreased markedly （ P 〈 0. 05 , P 〈 0. 01 ） , overgrowth of the heart muscle occurred as revealed by optical microscope , varying degrees of matrix edema and tissue cell hyperplasia appeared , and there were mild inflammation and fibrosis in the endocardium and pericardium. After the application of ICO and AG, the symptoms were relieved. Conclusion：ICO has protecting effect on type 2 diabetic cardiopathy.

关 键 词：山茱萸环烯醚萜总苷 2型糖尿病 胰岛素抗体 血脂 心脏病变 

分 类 号：R285.5[医药卫生—中药学]