头孢地嗪对新生儿败血症的临床疗效评价  

Clinical study on curative effect of cefodizime for neonatal septicemia

作　　者：徐灵敏[1] 贾莉婷[2] 张展[2] 邵斌[3] 任艳丽[3] 栾斌[1] 

机构地区：[1]郑州大学第三附属医院儿内科,450052 [2]郑州大学第三附属医院检验科,450052 [3]郑州大学第三附属医院药剂科,450052

出　　处：《中国急救医学》2007年第8期698-701,共4页Chinese Journal of Critical Care Medicine

基　　金：河南省教育厅自然科学研究科技攻关资助项目(No2007350007)

摘　　要：目的评价头孢地嗪(CDZ)对新生儿败血症的临床疗效。方法采用临床病例对照观察研究方法,把112例新生儿败血症患儿随机分为CDZ组(43例)和对照(CG)组,CDZ组抗生素首选CDZ50mg·kg-1·d-1,q12h;CG组随机选用其他β-内酰胺类药物,选用复方抗生素者为CG1组(33例),选用单方者为CG2组(36例)。统计分析首选抗生素5d内换药率及各组间预后的差异。结果112例患儿首选抗生素共6种,5d内换药率CDZ组为12%,其他5种抗生素为36%～66%,首选抗生素的换药率和最终治疗的有效率呈负相关(r=-0.888,P<0.05)。三组有效率比较差异均有统计学意义(P值均<0.05)。结论CDZ临床疗效好,可作为治疗新生儿败血症的新选择。Objective To investigate the clinical effects of cefodizime （CDZ） on neonatal septicemia. Methods The cases of 112 neonates with septicemia were divided into 3 groups at random . The CDZ group with 43 cases received 50 mg/kg CDZ, q 12h. The control group （CG） received other β - lactam antibiotics at random, compound antibiotics for the CG1 with 33 cases and simple antibiotics for the CG2 with 36 cases. The changing ratio in 5 days of first choice antibiotics and the prognosis of 3 groups were analyzed. Results There were 6 antibiotics as the first choice in the 112 cases. The changing ratio in 5 days was 12% for CDZ group, and the others were 36% - 66%. The prognosis of neonatal septicemia had negative correlation with the antibiotics changing ratio in 5 days （ r = - 0. 888, P 〈 0. 05 ）. There were statistical significance in the effective rates among the CDZ group （ 93% ） , CG1 group （ 73% ） and CG2 group（60% ） , all P 〈 0.05. Conclusion The C DZ has good clinical efficacy , and can be used as a new antibacterial choice for neonatal septicemia.

关 键 词：新生儿 败血症 头孢地嗪 抗生素 预后 

分 类 号：R722.1[医药卫生—儿科]