白介素-1受体拮抗物多态性与白塞病  

Interleukin 1 Receptor Antagonist Gene Polymorphism and Behcet's Syndrome.

作　　者：张军民[1] 刘贞富[1] 许彤华 杨琦[1] 张德美[1] 

机构地区：[1]同济医科大学附属协和医院皮肤科

出　　处：《中国皮肤性病学杂志》1997年第4期197-198,共2页The Chinese Journal of Dermatovenereology

摘　　要：为了解白介素 1受体拮抗物基因 (IL 1RN)是否为白塞病易感性和病损程度的遗传性标志 ,我们用PCR方法检查了 3 4例白塞病患者IL 1RN等位基因频率和携带率。结果 :病例组等位基因 2携带率、频率显著增加 ,且与病损严重度增加相平行。本研究提示IL 1RN等位基因 2与白塞病有强相关性。我们推测ILIn order to determine whether interleukin l receptor antagonist gene (IL 1RN) is a genetic marker of susceptibility and the ill extent of Behcetis syndrome,we checkd the frqeqency of its alleles in a group of 34 patients using the method of polymerase chain reaction (PCR).The result showed that there was a significant increase in allele 2 in the disease grup.The frequency of allele 2 was in parallel with disease extent.This suggested that IL 1RN may be a candidate gene or severity factor for Behcet's syndrom or may possibly be a liked marker to another,as yet unidentified gene.

关 键 词：白塞病 IL-1RN 多态性 病理 

分 类 号：R597.902[医药卫生—内科学]