中药腑安治疗术后肠麻痹的实验与临床研究  

Clinical and Experimental Study on the Treatment of postoperative Vleus with Herds Fuan(Abstract)

作　　者：冯秉安 张立志 黄磷 王选琛[1] 陈海波[1] 裴德恺[1] 王冬梅 李冬冬 杜闯[1] 姜美玲 程卫东 

机构地区：[1]大连大学医学院附属医院

出　　处：《大连医科大学学报》1997年第2期83-88,共6页Journal of Dalian Medical University

摘　　要：作者采用同位素标记液体试餐法观察大鼠腹腔手术后胃排空率，使用特异性一氧化氮（ＮＯ）合成酶抑制剂Ｌ—ＮＮＡ并检测胃肠组织中的ＮＯ含量，研究了ＮＯ在术后肠麻痹中的作用。结果揭示手术后胃排空显著延迟，而Ｌ—ＮＮＡ、腑安有明显改善术后肠麻痹的作用。中药腑安具有类似Ｌ—ＮＮＡ拮抗ＮＯ的作用。同时通过对腹腔手术及腹腔感染大鼠的研究，发现腑安能够降低内毒素、肿瘤坏死因子及自由基水平，保护肝脏及肺的功能。临床选用各种急腹症术后肠麻痹病人９０６例，应用腑安治疗，结果证实腑安临床疗效显著，无副作用。$$$$ Feng Bingan,et al Department of Surgery,Second Affiliated Hospital,Dalian Medical UniversityAbstract This work odserved the gastrointestinal motility after abdomenal operation,with using L—NNA and measuring NO level in digestive system,studied the function of NO in postoperative ileus.The results suggested that NO play an important role in postoperative ileus and herds Fuan have a similar effect to L—NNA. At the same time,by studying the rats with surgery procedure of abdomenal infection,it was found that Fuan could ameliorate the liver and lung injury by decreasing endotoxin、TNF and free radical level.Moreover,906 acute abdomen patients suffering operation were treated with Fuan,compared to the control,Fuan had good clinical effect on postoperative ileus and no side effect.

关 键 词：中药腑安 外科手术 胃肠运动 一氧化氮 内毒素 

分 类 号：R256.305[医药卫生—中医内科学]