口服枳术丸后人体内橙皮苷、柚皮苷的药代动力学研究  

Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan

作　　者：王喜军[1] 陈曦[1] 曹洪欣[2] 孙晖[1] 杨舸[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]中国中医科学院,北京100700

出　　处：《中国实验方剂学杂志》2007年第8期18-20,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部基础性工作专项"中药材标准及中医临床疗效评价标准"(2001DEA20010)

摘　　要：目的:阐明枳术丸的的人体药动学特性。方法:利用葡萄糖醛酸酶使血浆中的苷元与葡萄糖醛酸游离,用HPLC方法,测定血浆中柚皮素(naringenin)及橙皮素(hesperetin)的含量,并用3p97软件进行数据分析。结果:柚皮素及橙皮素的T1/2(ka)/T1/2(ke)(h)分别是2.142±0.999/5.491±3.926和2.106±0.728/5.824±3.067,AUC(mg/L.h)分别是34.886±22.199和39.407±19.535,两种化合物的行为基本一致,生物利用度均较高。结论:建立了口服枳术丸后血浆中柚皮素及橙皮素的含量测定方法,并阐明了药动学特性,可用于指导该药的临床应用。Objective： Elucidating the pharmacokinetic properties of Zhizhu Wan. Method： By using β- Glucuronidase, free hesperintin and naringenin were obtained from the hesperetin-glucronide naringenin-glucronaide in plasma, the contents of the two compounds in plasma was determined by HPLC. Results： T1/2 （ka）/T1/2 （ ke ） （ h ） for naringenin and hesperetin are 2. 142 ＋_ 0.999/5.491 ± 3.926 and 2. 106 ± 0.728/5.824 ± 3.067 respectively, and the AUC （mg/L· h） value are 34. 886 ± 22. 199 and 39.407 ± 19. 535 for naringenin and hesperetin respectively. Conclusion： The method for determinning naringenin and hesperetin in plasma has been established, and the pharmacokinetic parameters can be instructive for clinic apllication.

关 键 词：枳术丸 柚皮素 橙皮素 药动学 

分 类 号：R285.5[医药卫生—中药学]