氨氯地平并苯那普利对高血压患者血浆一氧化氮与内皮素的影响  

Effects of amlodipine and benazepril combined treatment on plasma nitriogen monooxidum and endothelin in patients with hypertension

作　　者：孙一荣[1] 张云[1] 郝明泽[1] 孙泽刚[1] 

机构地区：[1]聊城市第二人民医院心内科,山东临清市252600

出　　处：《心血管康复医学杂志》2007年第4期374-376,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:评价氨氯地平、苯那普利单独和联合治疗对高血压患者血浆一氧化氮(NO)和内皮素(ET)的影响。方法:选择126例高血压患者随机分为3组,氨氯地平组(A组,41例,接受氨氯地平治疗);苯那普利组(B组,45例,接受苯那普利治疗);联合治疗组(C组,40例,接受氨氯地平和苯那普利治疗)。于治疗前、后行血压及血浆NO、ET测定,并与40例正常对照组血浆NO、ET水平对照。结果:较之对照组,三组高血压患者NO水平显著降低(P<0.01),ET水平显著升高(P<0.01)。三组治疗后血压、ET水平均有显著下降(P均<0.01),A组及B组下降幅度无显著差异,C组下降幅度明显高于A组和B组的(P<0.05);三组血浆NO水平均有显著升高(P均<0.01);A组及B组血浆NO水平升高无显著差异(P>0.05),C组NO升高幅度明显高于A组和B组的(P<0.05)。结论:氨氯地平和苯那普利单独治疗均可明显降低血压和血浆ET水平,同时升高血浆NO水平,而两药联用疗效更佳。　Objective：To study the effects of amlodipine and benazepril used individually or in combination on plasma nitrogen monooxidum（NO）and endothelin（ET）in patients with essential hypertension（EH）.Methods：A total of 126 cases with EH were divided randomly into three groups：amlodipine group（group A,n=41）;benazepril group（group B,n=45）;combined treatment group（group C,n=40,treated with amlodipine and benazepril）.The blood pressure,plasma NO and ET were measured before and after treatment.The 40 healthy subjects selected as control group.Results：The plasma NO level significantly decreased,ET level significantly increased（P〈0.01 all）in three EH groups,compared with normal control group.After treatment,the blood pressure,ET level significantly reduced（P〈0.01）,the level of plasma NO significantly increased（P〈0.01 all）in three groups.The effect of group A and B was no significant differance（P〈0.05）.The effect of group C were more obvious than that of group A and group B（P〈0.05）.Conclusion：The amlodipine combined with benazepril has additive effects on decrease blood pressure and ET level and increase NO level than those of amlodipine or benazepril used alone.

关 键 词：高血压 氨氯地平 苯那普利 一氧化氮 内皮素 

分 类 号：R544.1[医药卫生—心血管疾病]