地尔硫卓对高血压性心脏病左室舒张功能及血脑钠素的影响  

Effect of diltiazem on ventricular diastolic function and BNP in patient with hypertensive heart disease complicated left ventricular diastolic dysfunction

作　　者：许丽华[1] 刘漩[1] 于巍巍[1] 

机构地区：[1]佳木斯市中心医院ICU,黑龙江佳木斯154002

出　　处：《心血管康复医学杂志》2007年第4期394-396,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察高血压性心脏病(高心病)左室舒张功能不全(LVDD)患者地硫尔卓(合贝爽)治疗前、后血清脑钠素(BNP)的变化,及BNP与LVDD的关系。方法:合并LVDD的原发性高血压病人60例,每日给予合贝爽90～180mg口服,监测血压的同时,分别于用药前,和服药后1年,测量二尖瓣舒张早期血流峰值(E)速度、舒张晚期血流峰值(A)速度、及等容舒张时间(A2-O)值、并测定BNP水平,比较治疗前后E、A、A2-O值和BNP的变化。结果:治疗一年后患者的(1)收缩压及舒张压较治疗前明显下降(P<0.05);(2)E、A峰及A2-O值改善明显(P<0.05);(3)血清BNP水平明显下降(P<0.05);(4)血清BNP与E/A呈显著负相关(r=-0.694,P<0.05)。结论:(1)地硫尔卓能有效控制血压,改善高心病患者的左室舒张功能;(2)血清BNP水平能反映LVDD水平。　Objective：To study the effect of diltiazem（herbesser）on ventricular diastolic function and BNP in patient with hypertensive heart disease complicated left ventricular diastolic dysfunction.Methods：There were 60 patients who had been diagnosing hypertension heart disease with LVDD.They treated with Herbesser 90～180 mg/d.Their blood pressure、E、A、A2-O and the BNP were detected before therapy and one year after treatment.Results：One year after treatment：（1）The SBP and DBP significantly decreased（P〈0.05）;（2）The E、 A and A2-O obvioursly improved（P〈0.05）;（3）The BNP obvioursly decreased（P〈 0.05）;（4）The BNP significantly negatively correlated with E/A（r=-0.694,P〈0.05）in hypertension heart desease patients with LVDD.Conclusion：（1）Treatment with diltiazem can effectively control the blood pressure and improve the E/A in hypertensive heart disease patients with LVDD;（2）The concentrations of BNP has significant diagnostic value for the patients with LVDD.

关 键 词：地尔硫卓 高血压 利钠素 脑 心室功能 左 

分 类 号：R541.3[医药卫生—心血管疾病]