TCDCANa的合成及与CDCANa的药效对比  

The preparation and comparison of pharmacodynamics between sodium taurochenodeoxycholate and sodium chenodeoxylate

作　　者：公瑞煜[1] 都丽萍[1] 吕志良[1] 李建蓉[2] 乔学亮[3] 

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030 [2]华中科技大学同济医学院基础医学院,湖北武汉430030 [3]华中科技大学材料学院,湖北武汉430074

出　　处：《功能材料》2007年第8期1348-1351,共4页Journal of Functional Materials

基　　金：国家科学基金资助项目(30160083);华中科技大学同济医学院基金资助项目(00MY21-30);华中科技大学基金资助项目(02022Y-12)

摘　　要：以鹅去氧胆酸和牛磺酸为基本原料制备了牛磺鹅去氧胆酸钠,收率63.4%,纯度≥92%,以TLC和IR法确定其结构。并将牛磺鹅去氧胆酸钠与鹅去氧胆酸钠进行平喘、抗炎和解热对比实验。药理实验结果为:牛磺鹅去氧胆酸钠和鹅去氧胆酸钠的平喘作用解痉率分别为(80.2±23.4)%和(73.3±22.7)%,抗炎作用抑制率分别为45.6%和36.8%,解热作用发热后90min时ΔT分别为(0.54±0.5)和(0.60±0.4)℃,牛磺鹅去氧胆酸钠与鹅去氧胆酸钠间存在显著性差异。药理实验表明牛磺鹅去氧胆酸钠具明显的平喘、抗炎和解热作用,其作用强于鹅去氧胆酸钠。　The sodium taurochenodeoxycholate（TCDCANa） was prepared by conjugating starting compound chenodeoxycholic acid with taurine.The yield and the purity of synthetic product was over 63.4% and 92%.Its structure was determined by TLC and IR.Antiasthmatic test,anti-inflammatory test and allaying the fever test were made with sodium chenodeoxycholate（CDCANa） and TCDCANa.The result of TLC and IR shows that the product was TCDCA.The results of pharmacodynamics showed that an antispasmodic rate of（80.2±23.4）% and（73.3±22.7）%,rate of inhibition of 45.6% and 36.8% and after fever ΔT of（0.54±0.5） and（0.60±0.4）℃ at 90 min.They were significant difference in all those data between TCDCANa and CDCANa（P〈0.01）.It is proved that TCDCANa has more evident antiasthmatic,anti-inflammatory and allaying the fever effects than CDCANa has.

关 键 词：牛磺鹅去氧胆酸 合成 药效学 

分 类 号：R285.5[医药卫生—中药学]