曲司氯胺治疗逼尿肌过度活动症  

Application of Trospium Chloride in Treatment of Overactive Bladder (review)

作　　者：莫其聪[1] 廖利民[2] 李东[2] 

机构地区：[1]中国康复研究中心北京博爱医院药剂科,北京市100068 [2]中国康复研究中心北京博爱医院泌尿外科,北京市100068

出　　处：《中国康复理论与实践》2007年第8期750-752,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：曲司氯铵作为一种抗胆碱药物,有着良好的水溶性和周围的非选择性抗胆碱能活性,可以减弱膀胱逼尿肌收缩,降低其紧张度,显著增加膀胱容量,提高膀胱顺应性。多中心研究表明,该药的效能与奥西布宁相当,而优于托特罗定。曲司氯铵有与其他抗胆碱药物同样的不良反应,但由于其结构特点,无中枢系统毒性,在神经泌尿康复方面具有一定的作用。Trospium chloride is an anticholinergic agent with predominantly peripheral nonselective antimuscarinic activity and water solubility. It has potential therapeutic value in decreasing detrusor contracivity and tonity, so as to increase predominantly mean maximal bladder capacity and compliance. Muhicenter studys showed that the tolerability and efficacy of trospium chloride was as same as oxybutynin and better than toterodine. Adverse events of trospium chloride is the same as other anticholinergic agents, however its specially constitutional feature so as not to have toxicity to central nervous system. Trospium chloride has potential therapeutic value in the neurourological rehabilitation.

关 键 词：逼尿肌过度活动症 尿失禁 脊髓损伤 最大膀胱容量 曲司氯铵 综述 

分 类 号：R971[医药卫生—药品]