高血脂对腹膜透析患者的残余肾功能影响  

The Effect of Hyperlipidemia on Residue Renal Function of Patients on Peritoneal Dialysis

作　　者：张琪琦[1] 安惠霞[2] 姜国涛[3] 刘素雁[2] 

机构地区：[1]武警黄金第一总队医院,哈尔滨150081 [2]哈尔滨医科大学附属第二医院肾脏内科,哈尔滨150086 [3]天津市第五中心医院肾内科,天津300450

出　　处：《中国中西医结合肾病杂志》2007年第8期466-468,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：黑龙江省教育厅基金资助项目(No.10531122)

摘　　要：目的:观察高血脂对连续性不卧床腹膜透析(CAPD)患者的残余肾功能(RRF)的作用。方法:定期监测共72例CAPD患者血脂成分及残余肾功能,根据血脂的变化将患者分为胆固醇(TC)增高组、三酰甘油(TG)增高组及二者均增高组与TC、TG正常组,比较各组残余肾功能变化。结果:CAPD治疗初期残余肾功能无明显变化(P>0.05)。第12月时,TC增高组RRF较同组透析初月时下降(P<0.05)。TG增高组及TC、TG均增高组的RRF分别与透析初月时同组RRF比较显著下降(P<0.001)。第18月时3个血脂增高组RRF与TC、TG组比较均有下降(P<0.05)。RRF下降数值与TC(r=0.234,P<0.05)、TG(r=0.528,P<0.05)均呈正相关。结论:CAPD患者的RRF随着透析时间的延长而降低。高血脂与RRF改变值有正相关性。Objective：To investigate the effect of hyperlipidemia on the residue renal function （RRF） in patients of continuous ambulatory peritoneal dialysis （CAPD）. Methods： Seven - two patients were divided into four groups based on level of plasma cholesterol and triglyceride, including hypercholesterolemia group （lst）, hypertriglyceridemia group （2nd）, group with both raised （3rd）, group with normal lipidemia （4th）. Results：There were no significant changes in residual renal function at the beginning of therapy （P〉0.05）. Except for the fourth group, RRF at the 12th month was significantly lower than that at the 1st month when compared in same group. When compared with the fourth group, residual renal function of group with hyperlipemia was significantly lower at the 18th month （P〈0.05）. The difference of RRF was positively correlated with the plasma concentration of TC and TG. Conclusion： The decrease in RRF is time- dependent in patients underwent CAPD. Hyperllpidemia is positively correlated with decline in RRF.

关 键 词：高血脂 连续性不卧床腹膜透析 残余肾功能 

分 类 号：R692.5[医药卫生—泌尿科学]