肿瘤医院感染病原菌分布特点及耐药性分析  

Pathogenic Bacteria in Tumor Hospital:A Clinical Analysis of Their Distribution and Drug Resistance

作　　者：冯笑峰[1] 

机构地区：[1]山西省肿瘤医院,山西太原030013

出　　处：《中华医院感染学杂志》2007年第8期1018-1020,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析肿瘤专科医院感染病原菌的分布及耐药性特点,为肿瘤合并感染的合理用药提供依据。方法细菌鉴定用VITEK-32全自动微生物分析系统及常规法鉴定;药敏试验采用K-B纸片扩散法。结果从3年的临床送检标本中共检出病原菌1 280株,其中G-杆菌874株,G+球菌416株;铜绿假单胞菌、大肠埃希菌、不动杆菌属、肠杆菌科和克雷伯菌属的构成比分别是14.92%、14.92%、14.06%、13.91%和10.47%;D群链球菌与金黄色葡萄球菌的构成比是24.06%与7.70%,大肠埃希菌与金黄色葡萄球菌的耐药情况严重;对G-杆菌的可选药物主要有亚胺培南和头孢哌酮/舒巴坦等,对G+球菌的可选药物主要有万古霉素、阿米卡星等。结论肿瘤医院临床感染病原菌的分布与耐药特点与一般性综合医院非常类似,参考后者的相关信息对肿瘤医院合理使用抗菌药物和控制医院感染有重要意义。OBJECTIVE To characterize the pathogenic distribution and drug resistance of nosocomial infection occurred in tumor hospital and therefore provide the information in rational administration of antibiotics to tumor patients complicated with infection. METHODS Flora cultivation and isolation were operated with the methods described by the National Clinical Laboratory Operational Regulations. Flora was identified with the VITEK-32 automatic identifier, and bacteria-susceptibility test was operated with Kirby-Bauer method. RESULTS Totally 1280 strains of pathogenic bacteria were isolated; they comprised 874 strains of G^- bacteria and 416 strains of G^＋ bacteria. In this study, the isolation rates of Pseudomonas aeruginosa, Escherichia coli, Acinetobacter, Enterobacteriaceae and Klebsiella were 14.92%, 14.92%, 14.06%, 13.91% and 10.47%, respectively;whereas that of Streptococcus Group D and Staphylococcus aureus were 24.06% and 7. 70%, respectively. Both E. coli and S. aureus were much resistant to antimicrobial agents tested; while imipenem and vancomycin might be chosen for the G^- and G^＋ bacteria infection. CONCLUSIONS The bacterial spectrum and their drug-resistance characteristics in the tumor hospital are quite similar to that encountered in general hospitals. So the information on nosocomial infection control from the latter is of great importance in directing on and carrying out the same job in tumor hospital.

关 键 词：病原菌 耐药性 抗菌药物 肿瘤 

分 类 号：R378[医药卫生—病原生物学]