新生儿呼吸道感染病原菌分布及耐药性  

Pathogenic Bacteria in Respiratory Infection in Newborns:Their Distribution and Drug Resistance

作　　者：丁金龙[1] 应群华[1] 屠凤娟[1] 严文卫[1] 杨丽[1] 

机构地区：[1]绍兴市妇幼保健院,浙江绍兴312000

出　　处：《中华医院感染学杂志》2007年第8期1021-1023,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨引起呼吸道感染病原菌的菌株分布,并对其耐药性进行分析,为临床治疗提供用药依据。方法对709例新生儿上呼吸道感染患儿咽拭子进行常规细菌培养鉴定,用K-B法测定病原菌耐药性。结果共分离出438株菌,以革兰阴性杆菌为主,占70.3%,其中流感嗜血菌、肺炎克雷伯菌分别占39.8%和10.3%,真菌占23.5%,革兰阳性菌占6.2%。结论大多数病原菌对青霉素、氨苄西林耐药;头孢西丁、阿米卡星、万古霉素、亚胺培南、第三代头孢类抗菌药物敏感性较好。OBJECTIVE To investigate the distribution and drug resistance of pathogenic bacteria which caused respiratory infection among suscepted patients and offer scientific basis for reasonable usage of antibiotics. METHODS Oropharyngeal swabs among 709 cases of respiratory infection neonates were investigated by the routine methods and drug resistance was analyzed by K-B method. RESULTS Totally 438 bacterial strains were isolated from 709 neonates, most of these bacteria were Gram-negative bacilli （70. 3%）, among which Haemophilus influenzae and Klebsiella pneumoniae were accounted for 39.8% and 10.3%, respectively; fungi and Gram-positive cocci were accounted for 23. 5% and 6. 2%. CONCLUSIONS Most strains present higher resistance rates to penicillin and ampicillin; but cefoxitin, amikacin, vancomycin, imipenem and the third generation cephalosporins are revealed with higher sensitivity rates for pathogenic bacteria in newborns.

关 键 词：呼吸道感染 咽拭子 耐药性 

分 类 号：R378[医药卫生—病原生物学]