急性有机磷农药中毒致多器官功能衰竭危险因素的研究  

Risk factor for multiple organ dysfunction syndrome caused by acute organic phosphorus poisoning

作　　者：金抗[1] 朱庆莲[2] 

机构地区：[1]中国医科大学附属第一医院急诊科,辽宁沈阳110001 [2]沈阳市第五人民医院急诊科

出　　处：《中国医科大学学报》2007年第4期460-462,共3页Journal of China Medical University

摘　　要：目的:探讨急性有机磷农药中毒(AOPP)发生多器官功能衰竭(MOF)的危险因素和病死率。方法:把130例AOPP病例分为MOF组及非MOF组,将两组各项指标进行比较。结果:单因素分析提示:患者口服有机磷农药的剂量、24h内ALT、TBIL、LDH、BUN、Cr、Glasgow昏迷评分(GCS),服药至洗胃时间、体温,既往病史、抢救过程中血液灌注与否在两组间差异有统计学意义;年龄、性别、洗胃与否与便潜血,CK、CKMB、CHE两组间差异无统计学意义。多因素Logistic回归分析:服药至洗胃时间,慢性病史,TBIL和GCS分值对发生MOF有显著影响。结论:可以用TBIL及GCS评分作为AOPP患者可能发生MOF的参考指标,服药至洗胃时间长,既往有慢性病史也是危险因素。Objective：To evaluate the risk factors for multiple organ failure （MOF） caused by acute organic phosphorus poisoning （AOPP） and the mortality of MOF. Methods： A total of 130 patients with AOPP were divided into MOF group and non-MOF group. The between-group differences were analyzed. Results： There were significant between-group differences for poison dose,alanine aminotransferase （ALT）,total bilirubin （TBIL）,lactate dehydrogenase （LDH）,blood urea nitrogen （BUN）,serum creatinine （Cr）,Glasgow Coma Scale （GCS）,past history,number of patients received blood transfusion,body temperature,and gastric lavage time. But no significant between-group differences for sex,age,poison category,positive stool blood,creatine kinase （CK）,creatine kinase MB isoenzyme （CK-MB）,and acetylcholinesterase （ChE） were found. Logistic regression indicated that the gastric lavage time,past history of chronic diseases,TBIL,and GCS affected the occurrence of MOF. Conclusion： TBIL and GCS could predict the occurrence of MOF. The delayed gastric lavage and past history of chronic diseases are also the risk factors for MOF.

关 键 词：急性有机磷农药中毒 多器官功能衰竭 危险因素 

分 类 号：R505.97[医药卫生—内科学]