1500名儿童重组乙型肝炎疫苗免疫效果观察  

Effects of gene recombining hepatitis B vaccine immunization in 1500 children

作　　者：戎秀娟[1] 

机构地区：[1]临沂市疾病预防控制中心,山东临沂276001

出　　处：《中国校医》2007年第4期399-401,共3页Chinese Journal of School Doctor

摘　　要：目的评价临沂市儿童重组酵母乙型肝炎疫苗接种8年后的免疫效果。方法采取随机整群抽样法,采用固相放射免疫法(SPRIA)检测血清HBsAg、抗-HBs和抗-HBc水平,并对免疫后HBsAg阳性原因进行分析。结果1500名3～8岁儿童中HBsAg阳性率为0.47%,疫苗免疫保护率为89.00%,抗-HBc阳性率为2.07%,各年龄组比较差异无统计学意义。抗-HBs阳性率为44.47%,但随年龄增大抗体阳性率下降。几何平均滴度为58.03mIU/mL,各年龄组比较差异无统计学意义。在7例HBsAg阳性儿童中,57.14%儿童的母亲HBsAg阳性。结论重组酵母乙型肝炎疫苗接种3～8年后,免疫人群保护效果理想,HBsAg阳性率未随免疫时间延长而明显增加。重组酵母乙型肝炎疫苗接种后抗-HBs阳性率随年龄增大而下降,应加强血清学监测。Objective To evaluate the effects of gene recombining hepatitis B vaccine after 8 years immunization. Methods The multiple stratified cluster sampling was used in this epidemiological survey. The sampling children＇ s blood serum HBsAg, anti-HBs and anti-HBc were checked and measured by the solid phase radioimmunoassay （SPRIA）. The serological levels of these indexes and the causes of the children with HBsAg positive were analyzed. Results There were 1 500 cases surveyed and the total HBsAg positive rate was 0.47%. The vaccine protective rate was 89.00%. The total anti-HBe positive rate was 2.07%. The average anti-HBs positive rate was 44.47% and it was descending following the children growing. GMT was 58.03 mIU/mL, showing no statistical significance among the age groups. Among the HBsAg positive children, 57.14 % of the children＇s mothers were HBsAg positive also. Conclusions The protective effects of gene recombining hepatitis B vaccine immunization are significant in the children for 8 years. The HBsAg positive rate does not ascend obviously as the immunization time prolonging. As the anti-HBs positive rate might be descending following the children growing, we should strengthen the serological surveillance of hepatitis B.

关 键 词：乙肝疫苗 预防接种 

分 类 号：R186.3[医药卫生—流行病学]