从青阳参提取的新寡糖(英文)  

Carbohydrates from Cynanchum otophyllum

作　　者：赵益斌[1] 刘迪[1] 徐贵丽[1] 左国营[1] 张青[1] 

机构地区：[1]成都军区昆明总医院药剂科,云南昆明650032

出　　处：《西南国防医药》2007年第4期385-389,共5页Medical Journal of National Defending Forces in Southwest China

基　　金：国家自然科学基金资助项目(30572322);云南省自然科学基金资助项目(2005C0036Q)

摘　　要：目的:了解青阳参片中化合物的结构。方法:对青阳参(萝藦科)的乙酸乙酯提取物(即青阳参片)进行酸水解,用柱层析的方法分离水解产物,得到的纯化合物再用光谱方法测定结构。结果:分离得到4个新寡糖,结构被分别测定为:甲基2,6-二去氧-3-O-甲基-β-D-阿拉伯-己吡喃糖基-(1→4)-6-去氧-3-O-甲基-β-D-核-己吡喃糖基-(1→4)-6-去氧-3-O-甲基-α-L-核-己吡喃糖苷(1),甲基6-去氧-1,3-二-O-甲基-β-D-核-己糖基-(1→4)-2,6-二去氧-3-O-甲基-α-D-阿拉伯-己吡喃糖苷(2),甲基2,6-二去氧-3-O-甲基-β-D-阿拉伯-己吡喃糖基-(1→4)-6-去氧-3-O-甲基-α-L-核-己吡喃糖苷(3),和2,6-二去氧-3-O-甲基-β-D-阿拉伯-己吡喃糖基-(1→4)-2,6-二去氧-3-O-甲基-α-D-阿拉伯-己吡喃糖基-(1→4)-2,6-二去氧-3-O-甲基-β-D-来苏-己吡喃糖(4)。结论:青阳参片中的单糖残基为2-去氧己糖,残基间以1→4连接。　Objective：To know the structures of compounds in Qingyangshen Tablets.Methods：The acidic hydrolysis part of the EtOAc extract of Cynanchum otophyllum Schneid （Asclepiadaceae） was separated through column chromatography; the structures of the resulting compounds were determined by spectral methods.Results：Four new carbohydrates were isolated whose structures were determined as methyl 2,6-dideoxy-3-O-methyl-β-D-arabino -hexopyranosyl-（1→4）-6-deoxy-3-O-methyl-β-D-ribo-hexopyranosyl-（1→4）-6-deoxy-3-O-methyl-α-L-ribo-hexopyranoside （1）,methyl 6-deoxy-1,3-di-O-methyl-β-D-ribo-hexosyl-（1→4）-2,6-dideoxy-3-O-methyl-α-D-arabino-hexopyranoside （2）,methyl 2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-（1→4）-6-deoxy-3-O-methyl-α -L-ribo-hexopyranoside （3）,and 2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-（1→4）-2,6-dideoxy-3-O-methyl-α-D-arabino-hexopyranosyl-（1→4）-2,6-dideoxy-3-O-methyl-β-D-lyxo-hexopyranose （4）,respectively.Conclusion：Sugar residues in Qingyangshen Tablets were 2-deoxy-hexoses between which the linkage was 1→4 linkage.

关 键 词：青阳参 水解液 寡糖 

分 类 号：Q946.3[生物学—植物学]