清晨高血压与靶器官损害的研究  

Morning blood pressure surge and target organ damage

作　　者：郑霞[1] 王鑫[2] 朱艳利[2] 李文华[2] 高海青[3] 

机构地区：[1]山东省立医院保健心电图室,山东济南250021 [2]山东省立医院老年心血管科,山东济南250021 [3]山东大学齐鲁医院老年心血管科,山东济南250012

出　　处：《山东大学学报（医学版）》2007年第8期801-803,807,共4页Journal of Shandong University:Health Sciences

基　　金：山东省卫生厅基金资助项目(2005-3)

摘　　要：目的:应用24 h动态血压监测(24hABPM)分析老年人清晨高血压的近日节律特点并探讨其对心脏结构和电生理的影响以及对肾脏及血管内皮的损害。方法:根据24 h动态血压监测将201例老年原发性高血压患者分为晨峰组和非晨峰组,均常规检查血脂、空腹血糖,放免法测定尿微量白蛋白,计算体重指数(BMI)、左室质量指数(LVMI)、和QT离散度(QTcd)。结果:晨峰组的LVMI、QTcd和尿微量白蛋白指标均高于非晨峰组(P<0.01)。两组在性别、年龄、BMI、血脂方面差异无统计学意义。结论:老年人长期晨间血压负荷增加更易改变心肌重构和心电生理特征,增加心律失常发生率和血管内皮损伤,加速动脉粥样斑块的形成。Objective： To investigate the role of morning hypertension on cardiac structure and electrophysiology and on kidney and blood vessel endothelium damage. Methods： A total of 201 cases were divided into two groups： the morning blood pressure surge group and the morning blood pressure normal group based on the ？A-hour ambulate blood pressure monitoring profiles. Blood fat, microalbuminuria, body mass index（BMI）, left ventricular mass index （LVMI）and QT dispersion（QTcd）were determined. Results： LVMI, QTcd and microalbuminuria in the surge group were higher than those in the normal group （ P 〈 0.01 ）. There were no significant differences between the two groups in gender, age, BMI, and hypertension course. Condusions： Morning blood pressure surge can cause ventricular hypertrophy and reconstitution and cardiac conduction arrhythmia, changes blood vessel function, damages the heart, kidney and blood vessel endothelium, and so accelerates atherogenesis.

关 键 词：高血压 晨峰 靶器官损害 动态血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]