不同药物对高脂饮食诱导肥胖大鼠体重、体脂及空腹血清Ghrelin水平等的影响  

Effects of different medicines on body weight,fat mass,and fasting serum Ghrelin level of high-fat diet induced obese rats

作　　者：姜冬青[1] 杨利波[2] 边德志[3] 高燕燕[4] 

机构地区：[1]山东大学第二医院内分泌科,山东济南250033 [2]泰安市中心医院内分泌科,山东泰安271000 [3]济宁医学院临床学院,山东济宁272013 [4]青岛大学医学院附属医院内分泌科,山东青岛266003

出　　处：《山东大学学报（医学版）》2007年第8期804-807,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨西布曲明、非诺贝特、二甲双胍及托吡酯对高脂饮食诱导的肥胖雄性Wistar大鼠体重、体脂、血糖、血脂、胰岛素及空腹血清Ghrelin水平的影响。方法:将35只雄性高脂饮食诱导的肥胖大鼠按照体重随机分为五组,在继续高脂饲料喂养的基础上分别给予西布曲明(10 mg/kg)、非诺贝特(83.4 mg/kg)、二甲双胍(400 mg/kg)、托吡酯(53.6 mg/kg)4种药物干预以及空白干预,8周后处死大鼠,测量体重、体脂重量,取血检测血脂、血糖、胰岛素和Ghrelin。结果:非诺贝特和托吡酯均可显著减少肥胖大鼠的摄食量(P均<0.01)和体重(P<0.01,P<0.05),二甲双胍和西布曲明在对食欲没有显著影响的情况下也能减重(P<0.05,P<0.01);另外,西布曲明和非诺贝特可以显著减少体脂含量(P<0.05,P<0.01)。各组大鼠的血脂、血糖、胰岛素和空腹血清Ghrelin均无统计学差异(P>0.05)。结论:西布曲明、非诺贝特、二甲双胍及托吡酯均可较好地控制高脂饮食肥胖大鼠的体重,但对血清Ghrelin水平均无显著影响;其中西布曲明及非诺贝特还可以显著降低肥胖大鼠的脂肪含量。Objective： To assess the effect of sibutramine, fenofibrate, metfonnin and topiramate on body weight, fat mass, fasting serum glucose, lipids, insulin and Ghrelin levels of obese rats induced by a high-fat diet. Methods： Thirty-five obese male Wistar rats were randomly divided into five groups. They were respectively treated with water, sibutmmine（ 10 mg/kg）, fenofibrate（83.4 mg/kg）, metfonnin（400 mg/kg）and topiramate（53.6 mg/kg）and were also fed with a fat-rich diet for 8 weeks. Then they were executed and body weight, visceral fat mass, serum lipids, glucose, insulin and Ghrelin were determined. Results. Food intake and body weight were significantly decreased by fenofibrate and topiramate （P 〈0.01, P 〈0.01 and P 〈0.01, P 〈0.05）in obese rats. However, food intake was not significantly changed but body weight was significantly decreased by Metfonnin and sibutramine （P 〈 0.05, P 〈 0.01）. Body fat mass was significantly decreased only by sibutramine and fenofibrate（ P 〈 0.05, P 〈 0. 01 ）. There were no significant differences of serum lipids, glucose, insulin and Ghrelin among the groups （ P 〉0. 05）. Conclusion： These four medicines are effective on reducing body weight in obese rats with a fat-rich diet, but have little effect on serum Ghrelin. Furthermore, sibutramine and fenofibrate can noticeably reduce fat mass.

关 键 词：肥胖症 西布曲明 非诺贝特 二甲双胍 托吡酯 Ghrelin 

分 类 号：R589.2[医药卫生—内分泌] R332[医药卫生—内科学]