活性氮对肝脏微粒体谷胱甘肽转移酶1修饰激活的研究进展  

Advances in reactive nitrogen species mediated activation of hepatic microsomal glutathione transferase 1

作　　者：史强[1] 楼宜嘉[1] 

机构地区：[1]浙江大学药学院药理毒理与生化药学研究所,浙江杭州310058

出　　处：《中国药理学与毒理学杂志》2007年第4期297-300,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金资助课题(30070904);国家自然科学基金资助课题(30472112);国家自然科学基金资助课题(30672564)~~

摘　　要：活性氮导致肝脏微粒体谷胱甘肽转移酶1(MGST1)修饰激活是近年来研究热点之一,由于其半胱氨酸(Cys49)可感受亲电子剂等而被修饰,担任"感受器"角色,行使对机体的保护作用。以过氧亚硝酸盐和S-亚硝基谷胱甘肽为代表的活性氮,可引起MGST1的酪氨酸(Tyr92)和Cys49发生若干种修饰,包括硝基化、S-亚硝酰化、谷胱甘肽化、巯基氧化等,均可介导酶激活,其中Tyr92的硝基化修饰可望揭示MGST1的"第二个感受器",与机体对硝基化应激的保护机制相关。Reactive nitrogen species （RNS） mediated activation of hepatic microsomal glutathione transferase 1 （ MGST1 ） is a recent focus on MGST1 modifications. As exemplified by peroxynitrite and S-ni ne, RNS could trigger various modifications on Tyr92 and Cys49 of MGST1, including nitration, S-nitrosylation, glutathionylation, sulfhydryl oxidation, etc. , all of which contribute to the enhanced enzymatic activities. The particular importance is Tyr92 nitration, which represents a novel sensor of MGST1 involved in the protection mechanisms against nitrosative stress.This review summarized the recent advances in RNS mediated activation of MGST1, focusing mainly on its mechanisms.

关 键 词：微粒体 肝 谷胱甘肽转移酶 过氧亚硝酸盐 S-亚硝基谷胱甘肽 

分 类 号：R96[医药卫生—药理学]