Relationship of HLA-A,-Cw Polymorphisms with HIV/AIDS in Chinese Yi Ethnic Group of Sichuan Province  

作　　者：Kun-xue HONG Xiao-zhi LU Guang-ming QIN Jian-ping CHEN Yu-hua RUAN Hui XING Jia-hong ZHU Yi-ming SHAO 

机构地区：[1]National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention,Beijing 100050, China 2. Wuhan Institute of Biological Products, Wuhan 430060, China [2]Wuhan Institute of Biological Products, Wuhan 430060, China [3]Sichuan Center for Disease Control and Prevention, Chendu 610000, China

出　　处：《中国病毒学》2007年第4期301-306,共6页Virologica Sinica

基　　金：the 10th Five-Years Key Technologies R&D Program(2004BA719A01);973 Program (2006 CB 504207)

摘　　要：The relationship of HLA-A, -Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A, -Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic signifiance was determined by the χ2 test with the SPSS software. No significant differences were observed between the HLA-A, -Cw alleles of the 68 HIV-1 infected and 102 non-infected Chinese Yi control individuals. Whereas the prevalence of A*3601,Cw*14(01-03)and Cw*0304 was significantly higher in 21 long time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by χ2 or the Fisher exact test respectively. The result implies that A*3601,Cw*14(01-03) and Cw*0304 may be associated with slow AIDS disease progression in the Chinese Yi ethnic group, further studies on this association may yield insight on the pathogenesis of HIV-1 infection.The relationship of HLA-A, -Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A, -Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic signifiance was determined by the χ^2 test with the SPSS software. No significant differences were observed between the HLA-A, -Cw alleles of the 68 HIV-1 infected and 102 non-infected Chinese Yi control individuals. Whereas the prevalence of A＊3601,Cw＊14（01-03）and Cw＊0304 was significantly higher in 21 long time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by χ^2 or the Fisher exact test respectively. The result implies that A＊3601,Cw＊14（01-03） and Cw＊0304 may be associated with slow AIDS disease progression in the Chinese Yi ethnic group, further studies on this association may yield insight on the pathogenesis of HIV-1 infection.

关 键 词：艾滋病病毒 艾滋病 彝族 HLA-A HLA-CW 多态性 相关性 四川 

分 类 号：R373[医药卫生—病原生物学] R512.91[医药卫生—基础医学]