SC-CO_2纤维粘接法制备PLA/TCP/Collagen组织工程支架材料  

Preparation of tissue engineering scaffold materials PLA/TCP/Collagen(PTC) by supercritical CO_2 fiber bonding

作　　者：丁珊[1] 邢禹彬[1] 李立华[1] 周长忍[1] 

机构地区：[1]暨南大学材料科学与工程系,广州510630

出　　处：《材料研究学报》2007年第4期348-353,共6页Chinese Journal of Materials Research

基　　金：国家自然科学基金N32204056;广东省'十五'重大专项A302020104资助项目。~~

摘　　要：在超临界CO_2(SC-CO_2)循环萃取条件下制备PLA/TCP/Collagen(PTC)多孔组织工程支架材料,研究了胶原含量对支架材料的总孔隙率、开孔率、孔洞形态和力学性能的影响,以及胶原纤维在支架材料中的分布.结果表明:用SC-CO_2反复循环萃取法制备的PTC支架材料开孔率可达到82.81%,比不加胶原的PLA/TCP支架高约25%;孔径为200-500μm,孔洞之间出现重要的'隧道'结构;胶原纤维在SC-CO_2反复循环萃取法处理后保持着网络形态,在支架中分布均匀;胶原纤维加入使支架材料的压缩模量和压缩强度明显下降.The influences of the component proportion of collagen on the total porosity, open porosity, shape of the pore and mechanical capacity of engineer scaffold materials PLA/TCP/Collagen（PTC）, prepared with supercritical carbon dioxide （SC-CO2） fiber bonding technique, were investigated. The open porosity of the PLA/TCP/Collagen scaffolds can achieve 82.81% which was 25% higher than that of the PLA/TCP scaffolds; The diameter of the pores was 200-500μm and there were many tunnels among the pores. Collagen fiber can maintain the network shape after SC-CO2 processing and can be evenly compounded into the scaffolds. The compressure modulus and compressure strength of the scaffolds decline to 1.17 MPa and 0.17 MPa respectively when containing 0% collagen.

关 键 词：有机高分子材料 生物医学工程 组织工程支架材料 超临界CO2纤维粘结法 

分 类 号：TB324[一般工业技术—材料科学与工程]