白介素-11及可溶性糖蛋白130在急性白血病诱导缓解过程中的变化及其意义  

Level and clinical value of the plasm IL-11 and soluble gp130 in the patients with acute leukemia during the treatment of the induced remission

作　　者：张秋荣[1] 吴德沛[1] 苗瞄[1] 李彩霞[1] 吴小津[1] 陈令松[2] 曹若男[2] 

机构地区：[1]苏州大学附属第一医院血液科,江苏苏州215006 [2]徐州医学院第二附属医院血液科,江苏徐州22100

出　　处：《中国实用内科杂志》2007年第17期1376-1378,共3页Chinese Journal of Practical Internal Medicine

基　　金：苏州大学附属第一医院血液病学"135工程"重点学科开放课题基金(135XY0413);徐州市卫生局科研项目(XW2005056)

摘　　要：目的探讨白介素-11(IL-11)及可溶性糖蛋白130(sgp130)在初诊急性白血病(AL)诱导缓解过程中的变化及临床意义,研究基因重组人白介素-11(rhIL-11)对AL患者血小板恢复的影响。方法将苏州大学附属第一医院和徐州医学院第二附属医院血液科2004年4月至2005年10月收治的64例初诊AL患者分为A、B两组,采用ELISA检测方法对初诊AL患者(A组)化疗前及获完全缓解(CR)后的血清IL-11及sgp130质量浓度进行动态观测;将rhIL-11应用于初诊AL患者(B组)。结果AL患者血清IL-11明显低于正常人(P<0.05),经诱导化疗获CR后明显升高至正常水平,且与外周血血小板数呈平行性升高或降低;sgp130明显高于正常人(P<0.05),获CR后明显下降至正常水平,且与外周血白细胞数呈正相关。注射rhIL-11后血小板恢复至≥30×109/L、≥50×109/L、≥100×109/L的平均时间均早于未使用rhIL-11者,且血小板输注量明显减少。结论检测AL患者血清IL-11及sgp130水平可作为了解AL患者病情、判断疗效和预后的有意义的指标;rhIL-11可以有效地促进AL患者诱导缓解化疗后外周血小板的恢复。Objective To explore the levels and the significance of IL-11 and sgpl30 in the treatment of newly-diagnosed acute leukemia（AL）during the treatment of the induced remission,and to evaluate the curate effect of rhIL-11 on AL. Methods The levels of IL-11 and sgpl30 in patients with AL were determined by ELISA respectively before treatment and after completing remission（CR）. 1.5 mg of rhIL-11 was injected subcutaneously,once a day,continuously for 14 days as one course, of treatment time 1 - 2 courses as total. Results Plasm IL-11 level in AL patients was significantly lower than normal（ P 〈 0.05 ） , and increased obviously to the normal level when CR was achieved. And it correlated with PLT counts,while sgpl30 level was higher than normal（P 〈 0.05 ）, and declined after CR and correlated with WBC counts. Conclusion The serum IL-11 and sgpl30 levels can be helpful for confirming the diagnosis,evaluating the efficiency and predicting the prognosis of AL. RhIL-11 can effectively promote peripheral-platelet recovery after the treatment for acute leukemia patients.

关 键 词：白介素-11 可溶性糖蛋白130 基因重组人白介素-11 急性白血病 

分 类 号：R5[医药卫生—内科学]