血清C-反应蛋白与妊娠糖尿病的关系研究  

The relationship between C-reactive protein and gestational diabetes mellitus

作　　者：王静[1] 李苗[1] 

机构地区：[1]杭州市余杭区妇幼保健院,311100

出　　处：《浙江临床医学》2007年第8期1030-1031,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨血清C-反应蛋白(C-reactive protein,CRP)水平与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系。方法选取2002年6月至2006年6月本院门诊及住院患者经75g葡萄糖耐量试验(OGTT)确诊为妊娠期糖尿病患者(GDM)48例和糖耐量异常妊娠妇女32例,并随机选择同期相匹配的正常糖耐量妊娠妇女80例(作为对照组),同时检测空腹血清CRP水平。结果GDM组C-反应蛋白水平明显高于另两组(P<0.05);CRP水平与孕前体重指数(BMI)、空腹血糖、空腹胰岛素呈正相关,相关系数分别为0.348、0.156和0.296,P值分别为0.0001、0.0178和0.0004。直线回归方程y=0.0741x1+0.0147x2+0.0397x3-1.457,r2=0.2469。结论C-反应蛋白与GDM密切相关,参与了其发病机制。Objective To investigate the relationship between C- reactive protein（CRP） and gestational diabetes mellitus （GDM）. Methods We studied 160 healthy pregnant women undergoing oral glucose tolerance test. Based on oral glucose tolerance test and pre - pregnancy body mass index （BM1）, participants were divided into three groups： 1 ） normal glucose tolerance （NGT） （ n = 80）as control ; 2） impaired glucose tolerance （ n = 32） ; 3 ） GDM （ n =48）, the serum level Spearman correlation analysis and multivariate linear regression analysis was used, Results： CRP levels in GDM group were significantly higher than that of 1GT and NGT groups （ P 〈 0.01 ）. CRP was significantly correlated with pre - pregnancy BM1 （ r = 0. 348, P 〈 0. 0001 ）, followed by fasting blood glucose （r = 0.156, P = 0. 0178） and fasting insulin （ r = 0. 296, P = 0. 00046）. In multivariate linear regression analysis, the ,same results were observed. Conclusion CRP might play a rule in pathogenesis of gestational diabetes mellitus.

关 键 词：妊娠糖尿病 C-反应蛋白 体重指数 

分 类 号：R714.25[医药卫生—妇产科学] R587.1[医药卫生—临床医学]