半叶马尾藻多糖与5-氟尿嘧啶联合治疗对小鼠肿瘤的作用研究  

Influence of seaweed polysaccharide from sargassum comfusum and 5-FU on sarcoma S180 in mice

作　　者：刘秋英[1] 孟庆勇[2] 

机构地区：[1]广东省职业病防治院检验科,广东广州510300 [2]广东医学院分析中心,广东湛江524023

出　　处：《疾病控制杂志》2007年第4期349-351,共3页Chinese Journal of Disease Control and Prevention

基　　金：广东省湛江市重点科技攻关项目(Y200106)

摘　　要：目的研究半叶马尾藻多糖(SP)与5-氟尿嘧啶(5-FU)联合治疗对小鼠肿瘤的作用。方法称重法计算SP对小鼠S180肉瘤的抑瘤率及q值;常规方法进行白细胞计数、分类和血红蛋白测定;用酶法测定ALT和AST;二乙酰一肟法测定BUN;HE染色法观察肿瘤组织的形态学变化。结果单独应用SP和5-FU的抑瘤率分别为34 .2 %和50 .9 %,而在相同条件下,联合用药组抑瘤率为72 .2 %,与SP和5-FU单独应用相比有显著性差异(P<0 .01)。结论 SP与5-FU联合应用有协同抗肿瘤作用,SP可以提高肿瘤细胞对5-FU的敏感性,具有增效作用。To investigate the influence of seaweed polysaccharide from sargassum comfusum （SP） and 5-FU on the sarcoma S180 in mice. Methods The weight of S180 xenografts in mice was measured to calculate the inhibitory rate of SP on S180 tumor; HE dye was used to watch its morphological change. Results The inhibition rate of tumor growth on the sarcoma S180 was 34.2% and 50.9 % treated with single-agent SP and 5-FU respectively. SP therapy had no obvious effect on growth of tumors （P 〈 0.05）, and 5-FU therapy resulted in moderately less tumor volume than that in saline control group （P〈 0.05）. In contrast, the combined treatment with SP plus 5-FU led to a dramatic reduction in tumor volume compared with saline treatment, the inhibition rate attaining 72.2% （P〈0.01）. Furthermore, SP plus 5-FU showed significant difference compared with either agent alone. Conclusions SP could markedly enhance 5-FU chemosensitivity. So the combination therapy with SP plus 5-FU had further synergic antitumor activity beyond either agent alone.

关 键 词：氟尿嘧啶 抗肿瘤联合化疗方案 药物协同作用 

分 类 号：R114[医药卫生—卫生毒理学] R282.77[医药卫生—公共卫生与预防医学]