常见性病病原体感染与宫颈癌变相关性的初步研究  

A Study on the Rrelationship between Infections of Sexually Transmitted Pathogenic Microbes and Cervix Pathological Changes

作　　者：汤红峰[1] 张玉新[1] 林燕辉[1] 

机构地区：[1]广东省佛山市顺德第一人民医院,528300

出　　处：《齐齐哈尔医学院学报》2007年第13期1547-1549,共3页Journal of Qiqihar Medical University

基　　金：广东省医学科研基金项目(编号A2004680)

摘　　要：目的探讨常见性传播疾病(STD)病原体感染与宫颈癌变的关系。方法聚合酶链反应法检测子宫颈癌、宫颈上皮内瘤样病变(CIN)和正常宫颈组织中人乳头瘤病毒(HPV)16,18、单纯疱疹病毒II型(HSV-II)的表达,衣原体(CT)检测采用快速鉴定和解脲支原体(UU)采用培养法。结果HPV16,18、HSV-II、CT、UU在子宫颈癌及CIN组的表达与对照组的表达有显著性差异(P<0.05)。结论HPV感染是宫颈癌、CIN的高危因素;HPV16,18、HSV-II、CT、UU感染是宫颈糜烂的主要病原体,合并感染可促进宫颈病变的进程,导致宫颈癌的发生。Objective To investigate the relationship between cervical infection and the development of cervical cancerization. Methods HPV, HSV-Ⅱ were detected by using polymerase chain reaction （PCR）. CT was detected by quick coloration and UU by in vitro ctilture. Results Expression of HPV 16,18,HSV-Ⅱ,CT,UU in cervical cancer and CIN was significantly higher than that in control group （P〈0.05）. Conclusions HPV16,18-infections is the major element of cervical cancer and CIN. HSV-Ⅱ, CT, UU are the key element of cervical erosion. Their combination could strengthen the process of the disease and lead to the pathogenesis of cervical cancer.

关 键 词：宫颈癌 性传播疾病病原体 感染 

分 类 号：R698.202[医药卫生—泌尿科学]