2型糖尿病患者尿微量清蛋白与纤维蛋白原的关系  

Relationship of urinary microalbumin and fibrinogen in patients with type 2 diabetes mellitus

作　　者：伍松姣[1] 闭肇龙[1] 陈耀宇[1] 

机构地区：[1]广西中医学院附属瑞康医院检验科,南宁530011

出　　处：《检验医学与临床》2007年第9期839-839,841,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨2型糖尿病(DM)患者尿微量清蛋白(mAlb)与血浆纤维蛋白原(FIB)的关系。方法对167例2型DM患者和60例健康对照者采用比浊法测定血浆FIB,采用放免分析法测定24h尿mAlb,分析FIB与mAlb的关系。结果2型DM组的尿mAlb和血浆FIB均大于健康对照组(P<0.01);DM患者高FIB(>4.0g/L)组的mAlb水平高于正常FIB(2.0～4.0g/L)组(P<0.05)。直线相关分析显示,尿mAlb与FIB呈显著正相关(r=0.412,P<0.01)。结论2型DM患者血浆FIB与尿mAlb呈正相关,FIB测定在DM早期肾损害中有重要临床意义。Objective To explore the relationship of urinary microalbumin （mAlb） and fibrinogen （FIB） in patients with type 2 diabetes mellitus （T2DM）. Methods 167 patients with T2DM （T2DM group） and 60 healthy controls（control group）were enrolled in the study. Turbidimetric method was applied to measuring plasma FIB, and radioimmunaossay was applied to determinating 24 h urinary microalbumin. The relationship between FIB and mAlb was analysed. Results The levels of mAlb and FIB in T2DM group were significant higher than those in healthy control group （P〈0. 01）. In DM patients, the level of mAlb was higher significantly in elevated FIB （〉4. 0 g/L） group than that in normal level of FIB （2.0-4.0g/L） group （P〈0.05）. Correlation analysis indicated that there existed significant positive correlation between urinary mAlb and FIB（r=0. 412,P〈0.01）. Conclusion The plasma FIB is positively related to urinary mAlb in T2DM patients, and FIB determination has an important clinical significance in early renal injury during DM.

关 键 词：糖尿病 尿微量清蛋白 纤维蛋白原 

分 类 号：R587.2[医药卫生—内分泌]