双波长光学低相干干涉术用于血氧饱和度测量的数值分析  

Numerical Analysis on Oxygen Saturation Measurement in Human Retinal Blood Vessel by Dual-wavelength Optical Low-coherence Interferometry

作　　者：王玲[1] 丁志华[1] 黄丽娜[1] Martial Geiser 李娜[1] 

机构地区：[1]浙江大学现代光学仪器国家重点实验室,杭州310027 [2]Haute Ecole Valaisanne Sion,Switzerland

出　　处：《光子学报》2007年第B06期209-213,共5页Acta Photonica Sinica

基　　金：国家自然科学基金(60378041;60478040);浙江省自然科学基金(Z603003);教育部博士点基金(20030335099);霍英东青年教师基金(91010);教育部新世纪优秀人才支持计划和浙江省"新世纪151人才工程"资助

摘　　要：提出了采用双波长光学低相干干涉仪(Optical low coherence interferometer,OCI)来测量人体视网膜血管中血氧饱和度(Oxygen Saturation,SO2)的方法.详细阐述了双波长光学低相干干涉术用于血氧饱和度测量的基本原理,并分析了OCI中双波长的选择原则.基于内径为200μm的毛细玻璃管的简易人眼视网膜血管模型,分别模拟了光源中心波长为680 nm和820 nm时血液血氧饱和度由40%提高到60%时对应干涉信号的变化.数值分析表明,要判别20%的血氧饱和度变化,OCI系统灵敏度至少要达到70 dB.Dual-wavelength optical low-coherent interferometry is proposed to measure the oxygen saturation in human retinal blood vessel. Principle of oxygen saturation measurement based on dualwavelength low-coherence interferometer is thoroughly developed. The choice of wavelength is also analyzed. By taking a capillary with inner diameter of 200μm as the mode of human retinal blood vessel, a numerical simulation is carried out based on interference signal changes at the center wavelength of 680 nm and 820 nm respectively while oxygen saturation changes from 40% to 60%. The numerical study concludes that a system sensitivity of -70 dB is required for optical low-coherence interferometer to discriminate 20% increase in oxygen saturation.

关 键 词：光学低相干干涉术 双波长 血氧饱和度(SO2) 氧基血红素(HbO2) 无氧基血红素(Hb) 

分 类 号：TN247[电子电信—物理电子学]