3─烷氧羰基甲基硫甲基头孢菌素衍生物的合成及抗菌活性  

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3 ALKOXYCARBONYLMETHYLTHIOMETHYL CEPHALOSPORIN DERIVATIVES

作　　者：沈舜义[1] 张芸[1] 徐屹军[1] 

机构地区：[1]上海医药工业研究院

出　　处：《中国医药工业杂志》1997年第3期126-128,共3页Chinese Journal of Pharmaceuticals

摘　　要：合成了５个３－烷氧羰基甲基硫甲基头孢菌素衍生物。初步药理试验表明，化合物１对革兰氏阳性球菌有较强的抑制作用，ＭＩＣ为０．１～６．Five 3 alkoxycarbonylmethylthiomethyl cephalosporin derivatives were synthesized.Among them compound 1 a～e showed good in vitro antibacterial activity against Gram positive bacteria, MICs were 0.1～6.2 μg/ml.

关 键 词：头孢菌素 合成 抗菌活性 

分 类 号：TQ465.1[化学工程—制药化工] R978.11[医药卫生—药品]