吸烟对抗氧化类维生素和抗氧化酶活性的影响  

Effects of Cigarette Smoking on Antioxidant Vitamin and Activities of Antioxidases

作　　者：周君富 郭芳珍[1,2] 钱志君[1,2] 丁德云[1,2] 

机构地区：[1]浙江省药物滥用监测站 [2]浙江医科大学附属第二医院

出　　处：《中华预防医学杂志》1997年第2期67-70,共4页Chinese Journal of Preventive Medicine

摘　　要：为探讨吸烟与抗氧化类维生素及氧自由基的关系，我们检测了８７１例健康吸烟者和３４８例健康非吸烟者血浆维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）、过氧化脂质（Ｐ－ＬＰＯ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）活性。结果表明，与非吸烟组比较，吸烟组的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ显著降低，Ｐ－ＬＰＯ显著升高；６５例相同年龄男性吸烟者的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ和Ｅ－ＳＯＤ均随吸烟史及吸烟量的增加而降低，Ｐ－ＬＰＯ随吸烟史及吸烟量的增加而升高，并均呈一定程度的直线相关；提示吸烟者体内的氧化和抗氧化平衡严重失调，氧自由基反应和脂质过氧化反应明显加剧。Levels of plasma vitamin C and E (P VC,P VE), β carotene (P β Car), lipoperoxides (P LPO), and activity of erythrocyte superoxide dismutase (E SOD) were measured in 871 healthy smokers and 348 healthy non smokers to study the relationship between cigarette smoking and antioxidant vitamins and oxygen free radicals. Results showed that levels of P VC, P VE, P β Car and E SOD reduced significantly, and level of P LPO increased significantly in smokers, as compared with those in non smokers. Levels of P VC, P VE, P β Car and E SOD reduced and level of P LPO increased in 65 male smokers at the same age, with the increase of duration of smoking and quantity of cigarettes smoked, showing a linear correlationship. It suggested that there existed serious imbalance between oxidation and antioxidation in the bodies of smokers, and oxygen free radical reaction and reaction of lipoperoxidation obviously intensified.

关 键 词：吸烟 维生素 SOD 

分 类 号：R163[医药卫生—公共卫生与预防医学]