红景天苷及其类似物的合成  

Synthesis of salidroside and its analog

作　　者：邓梅[1] 吴振刚[1] 刘雪英[1] 孙晓莉[1] 

机构地区：[1]第四军医大学药学系化学教研室,陕西西安710033

出　　处：《第四军医大学学报》2007年第16期1501-1502,共2页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金项目(30600163;20302014);全军医药卫生科研基金课题(06G098)

摘　　要：目的:寻找一种合成红景天苷及其类似物的新方法.方法:以对羟基苯乙酸为原料,经乙酰化、还原、糖苷化、醇解反应合成了红景天苷及其类似物,总收率分别为63%,67%.结果:本实验缩短了反应步骤,提高了产率,且反应条件温和,操作简单易行.结论:本方法合成红景天苷及其类似物切实可行.AIM： To search a new method for the synthesis of salidroside and its analog. METHODS： Salidroside and its analog were prepared from 2-（ 4-hydroxyphenyl ）-acetic acid by acylation, reduction, glucosidation and alcoholysis, The total yields were 63% and 67% , respectively. RESULTS ： The new method shortened the reaction steps and increased the yield, and the reaction condition was mild, and the manipulation was simple. CONCLUSION： The method employed in this study is feasible.

关 键 词：红景天苷 红景天苷类似物 

分 类 号：R979.6[医药卫生—药品]