HLA-I类基因多态性与白血病易感性的关联性研究  

Correlation between gene HLA-class I polymorphism and susceptibility to leukemia

作　　者：周兰霞[1] 赵丽[1] 

机构地区：[1]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《西安交通大学学报（医学版）》2007年第4期406-408,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：甘肃省自然科学基金暨中青年基金资助项目(No.YS001-A23-020)

摘　　要：目的探讨白血病易感性与HLA-I类基因多态性之间的关联性,寻找白血病的易感基因。方法采用序列特异性寡核苷酸探针杂交技术(PCR-SSO)对65例白血病患者和48例正常对照组健康者进行HLA-A、B基因分型。结果在等位基因HLA-A、B中,白血病患者的HLA-A01、B38基因的基因频率高于正常对照组(P<0.05),而HLA-A11基因的基因频率明显下降(P<0.05)。结论基因A01、B38对白血病有遗传易感作用,而基因A11对白血病有遗传拮抗作用。To explore the correlation between gene HLA-class I polymorphism and susceptibility to leukemia in Chinese Gansu Han people and search for the genes susceptible to leukemia. Methods HLA-A and B alleles polymorphism in 65 patients with leukemia and 48 normal subjects were determined by PCR with sequence specific oligucleotide probe （PCR-SSO）. Results The allele frequencies of HLA-A01 and B38 were increased （P〈0.05）, while the allele frequencies of HLA-A11 were decreased in patients with leukemia （P 〈 0. 05）. Oonclusion HLA-A01 and B38 alleles seem to contribute to the genetic susceptibility to leukemia, while HLA-A11 seems to contribute to its genetic resistance.

关 键 词：HLA 白血病 PCR-SSO 多态性 

分 类 号：R392.12[医药卫生—免疫学]