1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮对肝星状细胞的影响  

Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)pyridone on hepatic stellate cells

作　　者：李萍[1] 陶立坚[2] 胡国龄[3] 谭德明[3] 

机构地区：[1]天津市传染病医院,天津市肝病研究所天津300192 [2]中南大学湘雅医院肾病研究所 [3]中南大学湘雅医院传染病研究所

出　　处：《中国临床药理学与治疗学》2007年第7期782-785,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨吡啶酮类化合物1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮(FMP)抗肝纤维化的机制。方法:MTT法观察FMP对肝星状细胞(HSC)增殖的影响,免疫细胞化学观察FMP对HSCⅠ、Ⅲ型胶原表达的影响。结果:FMP200、300、400、500、600μg/mL在24、48h可抑制HSC增殖,显著强于阳性对照组(P<0.05)。免疫细胞化学显示FMP在200μg/mL可抑制HSCⅠ、Ⅲ型胶原蛋白表达。结论:FMP治疗肝纤维化的原理可能与抑制HSC增殖和HSCⅠ、Ⅲ型胶原蛋白表达有关。AIM： To explore the mechanism of 1-（3- fluorophenyl ）-5-methyl-2- （ 1H ） pyridone （ FMP ） against hepatic fibrosis. METHODS： The inhibitory effect of FMP on hepatic stellate cells（HSC） proliferation was observed by MTF, and the expression levels of collagen type Ⅰ, Ⅲ protein of HSC were detected by immunocytochemistry. RESULTS： HSC proliferation was decreased after incubation with FMP for 48 h at the dosage range from 200μg/mL to 600 μg/mL compared with that in control group, and FMP could also significantly decrease the protein expression of collagen type Ⅰ, Ⅲ at the dosage of 200μg/mL. CONCLUSION： FMP can inhibit the proliferation of HSC and decrease the expression of type Ⅰ, Ⅲ collagen, which are related to the mechanism of FMP treating hepatic fibrosis.

关 键 词：1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮 肝星状细胞 肝纤维化 

分 类 号：R965.2[医药卫生—药理学]