重复给药对芬太尼诱发咳嗽的影响  

Effects of repeated administration of fentanyl on fentanyl-induced coughing

作　　者：张志永[1] 黄宇光[1] 周游[1] 任洪智[1] 罗爱伦[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院麻醉科,北京100730

出　　处：《中国临床药理学与治疗学》2007年第7期838-840,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察麻醉诱导时重复注射芬太尼对其诱发咳嗽(fentanyl-induced coughing)的影响。方法:300例择期手术患者,麻醉诱导前快速静注芬太尼1μg/kg,出现咳嗽的病人随机分为两组以同样的剂量和方法重复注射芬太尼:2min组在首次给药后2min注射;5min组在首次给药后5min注射。记录咳嗽发生的次数和出现时间,并根据咳嗽次数进行严重程度分级。结果:首次注射芬太尼1μg/kg诱发咳嗽的发生率为18%(54/300)。重复给药后,2min组的发生率为0%(0/27),5min组为40.7%(11/27),2min组发生率明显低于5min组(P<0.01)。咳嗽严重程度组间比较差异有统计学意义(P<0.01)、咳嗽出现时间比较差异无统计学意义(P>0.05)。结论:重复给药可明显降低麻醉诱导时芬太尼1μg/kg诱发的咳嗽发生率,但不影响其程度,而且随着给药间隔的延长,咳嗽发生率逐渐上升。AIM： To observe the effects of repeated intravenous administration of fentanyl 1 μg/kg on fentanylinduced coughing during anesthesia induction. METHODS： 300 patients with ASA Ⅰ or Ⅱ for elective procedures, received an intravenous injection of fentanyl 1μg/kg via a peripheral cannula prior to anesthesia induction. The patients who experienced cough were randomly divided into two equal groups according to the interval of repeated administration： group 2 min received the same dosage of fentanyl 2 min later and group 5 min was administrated the same dosage of fentanyl 5 min later. The occurrence of cough was recorded. The level of cough was graded. RESULTS： The incidence of fentanyl-induced cough in the first administration was 18% （54/300）. After repeated administration, the occurance of cough in group 2 min （0%, 0/27） was lower than that in group 5 min （40.7% ,11/27） （P 〈0.01）. There was significant difference on the severity between two groups （P 〈 0.01）. CONCLUSION： The incidence of fentanyl-induced coughing was significantly decreased after repeated administration of fentanyl 1 μg/kg during anesthesia induction, but the incidence of cough may be increased with the prolonging of the dosing interval.

关 键 词：芬太尼 咳嗽 重复给药 

分 类 号：R965.2[医药卫生—药理学]