介导感觉生理功能的瞬时受体电位通道蛋白(TRP)家族研究进展  

Progress in research on the function of transient receptor potential protein(TRP) family in sensory physiology

作　　者：孙滔[1] 张成岗[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《军事医学科学院院刊》2007年第4期369-371,共3页Bulletin of the Academy of Military Medical Sciences

基　　金：国家"973"计划项目(2006CB504100;2003CB715900);国家自然科学基金面上项目(30600365)资助

摘　　要：瞬时受体电位通道蛋白(TRP)家族由一类特殊的阳离子通道蛋白组成,在神经细胞及其他非兴奋细胞中有重要作用,其中在介导多种感觉生理功能方面的作用尤其显著。TRP结构与功能的深入研究为阐明感觉生理功能的分子机制提供了重要线索。本文综述TRP家族在温度感受、机械刺激感受、光感受和化学信号感受等方面的研究进展。The transient receptor potential protein （TRP） family consists of a group of diverse cation channels which play important roles in the nervous and non-excitable cells; however, an emerging theme is that many TRP-related proteins function in sensory physiology. The knowledge on structure and function of TRP family proteins has significantly facilitated the illustration of the molecular mechanism of sensory physiology. In this review, the current knowledge on the TRP family is summarised, and the impact of sensory physiology on TRP＇ properties is discussed, especially the advance in researches on the responses to temperature, mechanical forces, light, and chemical stimulation.

关 键 词：瞬时受体电位通道蛋白家族 感觉生理 信号转导 蛋白质转运 

分 类 号：Q42[生物学—神经生物学]