溃结康肠溶片的制备及体外释放度考察  

Preparation and Examination of the Vitro Releasing of pH-Dependent Kuijiekang Tablet for Colon-specific Delivery

作　　者：李瑞珍[1] 廖华卫[2] 陈飞苑[1] 

机构地区：[1]广州中山大学附属第三医院,广东广州510630 [2]广东药学院中药学院,广东广州510006

出　　处：《中药材》2007年第8期1025-1027,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:制备用于治疗溃疡性结肠炎的pH依赖-时间双重控制型结肠定位释药片,并建立其体外释放度检查方法。方法:以葛根素和盐酸小檗碱体外释放度为指标,对制剂的包衣处方进行筛选,采用体外释放度测定法考察该制剂的体外释放性能。结果:该制备工艺得到的片剂体外释放测定结果表明:在人工胃液中2 h时溶出度未检出葛根素和盐酸小檗碱,在人工小肠液4 h时两指标累计释放率均低于10%,而在人工结肠液1 h时葛根素和盐酸小檗碱累积溶出90.07%和89.87%。结论:制备得到pH依赖-时间双重控制型结肠定位释药片具有比较好的结肠定位释药目的。Objective：To prepare the pH-dependent kuijiekang tablet for colon-specific delivery used in treating the ulcerative colitis and to develop the in vitro release method of kuijiekang tablets. Methods ： The coating prescription was screened by the in vitro delivery of Puerarin and Berberine hydrochloride. The in-vitro releasing property of the preparation was examined by the method of in-vitro delivery. Results：The preparation methods of the pH-dependent kuijiekang tablet for colon-specific delivery was obtained, from the invitro delivery, Puerarin and Berberine hydrochloride were not detected in the simulated gastric fluid after 2 h and the quantified of Puerarin and Berberine hydrochloride were less 10% in the simulated intestinal fluid after 4 h. The quantities of Puerarin and Berberine hydrochloride were 90. 07% and 89. 87%, Conclusion：It can be prepared and the preparation is a promising delivery system for drugs to be delivery to the colon.

关 键 词：溃结康 结肠定位 PH依赖 时控 

分 类 号：R286.02[医药卫生—中药学]