酵母TOR信号转导途径  

TOR Signaling Pathway in Yeast

作　　者：蒋伶活[1] 闫智慧[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《细胞生物学杂志》2007年第4期478-482,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30571047)~~

摘　　要：TOR(target of rapamycin)是真核细胞中一种高度保守的与磷脂酰肌醇激酶相关的蛋白激酶(PIKK),它是免疫抑制剂/抗癌药物雷帕霉素(rapamycin)的靶物质。TOR是细胞生长的中枢控制因子,外界营养因素通过TOR的作用控制酵母、果蝇和哺乳动物细胞的生长。TOR根据细胞环境的营养条件做出相应的应答,参与调控蛋白激酶和蛋白磷酸酯酶的活性,从而控制与蛋白质合成和基因转录相关基因的表达。现对酵母细胞中TOR信号转导途径的研究进行简明的阐述。Target of rapamycin （TOR）, a member of the phosphatidylinositol kinase-related protein kinase （PIKK） family, is highly conserved in eukaryotes and regulates growth and proliferation of yeast, fly and mammalian cells. TOR promotes the phosphorylation of its downstream targets, leading to increased protein synthesis and decreased protein turnover, and therefore controls transcription and translation of nutrient-regulated genes in response to environmental changes of nitrogen or carbon sources. This review summarizes recent advances in studies on the TOR signaling in budding yeast.

关 键 词：酵母 信号转导 TOR 雷帕霉素 蛋白激酶 

分 类 号：R91[医药卫生—药学]