胞外ATP在男性生殖道中的作用(英文)  

The role of extracellular ATP in the male reproductive tract

作　　者：周文良[1] 左武麟[1] 阮晔纯[1] 王喆[1] 杜建阳[1] 熊原[1] 陈小章[2] 

机构地区：[1]中山大学生命科学学院生理学教研室,广州510275 [2]香港中文大学医学院生理学系上皮细胞生物学研究中心

出　　处：《生理学报》2007年第4期487-494,共8页Acta Physiologica Sinica

基　　金：This work was supported by the National Natural Science Foundation of China(No.30370540,30570229);the South China National Research Center for Integrated Biosciences in Collaboration with Zhongshan University.

摘　　要：胞外ATP除了能广泛作为神经递质外,还被认为是一种旁分泌或自分泌因子。ATP从男性生殖道中的精子或上皮细胞中释放,在调节各种生殖生理功能中起多种作用。本文综述了ATP调节附睾上皮细胞阴离子分泌的信号通路,阐述了ATP对依赖上皮细胞的输精管平滑肌收缩的调节机制,讨论了ATP在男性生殖道中的功能和作用。In addition to its well established role as a neurotransmitter, extracellular ATP has been considered as a paracrine/autocrine factor, either released from sperm or epithelial cells, in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions. This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis, as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens. Finally, the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed.

关 键 词：ATP 附睾 输精管 上皮分泌 平滑肌收缩 

分 类 号：R33[医药卫生—人体生理学]