参龙汤治疗老年血管性痴呆的临床研究  

Effects of Shenlong decoction on life quality of the aged patients with cerebral vascular dementia

作　　者：陈利平[1] 王发渭[1] 贾建军[1] 郝爱真[1] 

机构地区：[1]解放军总医院中医科

出　　处：《解放军医学杂志》2007年第8期866-868,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家中医药管理局中医药科技研究基金课题资助项目(2000-01LP07)

摘　　要：目的观察参龙汤治疗老年血管性痴呆(VD)的临床疗效。方法参照WHO公布的美国精神病学会VD诊断标准(DSM-IV),采用随机对照双盲法,将68例符合条件的老年VD患者分为治疗组和对照组。治疗组36例,口服中药参龙汤(主要成分为:人参6g、何首乌15g、仙灵脾12g、地龙15g、川芎10g、益智仁15g、生神曲10g等)3个月;对照组32例,服用脑复康3个月。选择简易智能量表(MMSE)、Blessed行为量表(BBS)于治疗前后进行比较,评估疗效。结果参龙汤、脑复康均可改善老年VD患者的认知功能、行为能力,对痴呆治疗的总体疗效相近;治疗后两组痴呆患者定向能力和短时记忆能力的改善较治疗前均有显著的提高(P<0.01),参龙汤可明显改善老年痴呆患者生活能力,与治疗前比较有显著性差异(P<0.01),而脑复康组治疗后与治疗前比较未能显示出有显著性差异,说明参龙汤在改善痴呆患者生活能力方面要优于脑复康。结论参龙汤对老年VD确有一定疗效,可改善老年血管性痴呆患者的智力和生活能力。Objective To investigate the clinical effects of Shenlong decoction （main ingredients consisted of ginsent mot, radix polygonimultiflori, Pheretima, Ligusticum wallichii, Fructas Alpiniae oryphyllee etc, ） on the treatment of cerebral vascular dementia （VD） in the elderly patients. Methods VD in all the patients （age： 72. 1±5. 3 years old） was diagnosed according to the APA criteria, and the cerebrovascular diseases were confirmed by CT or MRI. 68 patients were divided into 2 groups randomly. The experimental group consisting of 36 patients was given Chinese traditional medicine, Shenlong decoction, orally 500ml q, i. d. for 3 months, and the other 32 patients were given acetamide pyrrolidone （piracetarn） orally 1.6g, tid for 3 months as a control group. The MMSE （Mini Mental State Examination） and BBS （Bless Behaviour Schedule） were used to evaluate the cognitive function and the daily activity in those patients before and after treatment. Results After treatment, the scores of cognition and daily activity were improved in all the patients with VD. The effective rate in the Shenlong group was 52.8%, and 53. 13% in the piracetam group. There was no significant difference in the improvement of the short time memory and orientation ability between the two groups. However, compared with the control group, the score of daily activity was significantly improved in the Shenlong decoction group only （P〈0. 01）. This means Shenlong decoction was superior to piracetarn in improving activity of daily life with VD. Conclusion Chinese traditional medicine, Shenlong decoction, can improve the intelligence level and the life quality of the aged patients with VD.

关 键 词：痴呆 血管性 中药疗法 老年人 

分 类 号：R954.73[医药卫生—药学]