FAIR肺实质MRI灌注成像的可行性研究  

Study on the Feasibility of Pulmonary Parenchyma MRI with FAIR

作　　者：范丽[1] 刘士远[1] 孙非[2] 孙玮[2] 肖湘生[1] 董伟华[1] 

机构地区：[1]第二军医大学附属长征医院影像科,上海200003 [2]通用电气中国医疗集团

出　　处：《实用放射学杂志》2007年第8期1033-1036,共4页Journal of Practical Radiology

基　　金：上海市科委基础重点项目(编号:03JC14009);长征医院"三重三优"优秀学科带头人基金项目(编号:20060109)

摘　　要：目的探讨FAIR在肺实质MRI灌注成像中的可行性。方法用GE 1.5T Excite HD磁共振成像系统(GE Healthcare,Milwaukee)对20例健康志愿者,结合心电门控技术在心脏舒张中期、呼气末屏气状态下行冠状面FAIR扫描。分别计算每个志愿者不同层面右肺与左肺的灌注值(PBF)并计算其比值(PBFR/PBFL,R/L)。结果20例志愿者均能较好的配合检查。在2个不同冠状面均获得SNR较高的灌注图像,左、右两肺的灌注相对较均匀。①经胸主动脉中央层面:右肺灌注为86.83±23.91,左肺灌注为86.86±27.44;左、右两肺灌注无明显统计学差异(P=0.9806>0.05);R/L为1.0103±0.0395。②经肺门层面:右肺灌注为40.86±14.56,左肺灌注为74.35±24.99;左、右两肺灌注有明显统计学差异(P=0.0001<0.05);R/L为0.5470±0.0477。③2个不同层面R/L的差异为(45.84±5.39)%。结论FAIR用于MRI肺灌注成像是可行的,由于质子饱和效应的因素,在个别层面左、右肺的灌注有差异。Objective To evaluate the feasibility of flow sensitive alternating inversion recovery（FAIR） in plumonary parenchyma perfusion imaging. Methods A total of 20 healthy volunteers were undergone SSFSE - FAIR imaging with breath - holding at the end of expiration and cardiac gating on a clinical 1. 5 T GE Excite HD whole body system （ GE Healthcare, Milwaukee ）. Two coronal perfusion - weighted MR images were acquired, one was the posterior coronal slice, and the other was the middle slice parallel to the right pulmonary artery. The perfusion values of bilateral lungs were calculated respectively and the right to left lung perfusion ratio（R/L） was also evaluated. Results All volunteers cooperated well during the examination and high quality perfusion images were acquired. On the posterior coronal slice, there was no significant statistical difference between right and left lung perfusion （ P = 0. 9806 〉 0.05, right lung 86.83 ±23.91, left lung 86.86 ±27.44, R/L 1. 0103±0. 0395 ）. While on the middle coronal slice, the perfusion values of right and left lung had significant statistical difference （ P = 0. 0001 〈 0.05,right lung 40.86 ± 14.56, left lung 74.35± 24.99, R/L 0. 5470 ± 0.0477 ）. The difference of ratio （R/L） in the posterior and middle slice was （45.84± 5.39） %. Conclusion Pulmonary perfusion with FAIR is feasible, but the perfusion of right and left lung may be different on certain slice due to spin saturation effect.

关 键 词：肺 灌注 磁共振成像 动脉自旋标记 

分 类 号：R322.35[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]