2型糖尿病非糖尿病一级亲属中肥胖患者血浆内脂素水平  

Plasma visfatin level in obese patients of nondiabetic first-degree relatives of type 2 diabetes

作　　者：刘军[1] 查英[1] 王芳[1] 陈灶萍[1] 徐炯[1] 盛励[1] 许火根[2] 廖晓寰[3] 郭瑜琳[4] 

机构地区：[1]复旦大学附属上海市第五人民医院内分泌科,上海200240 [2]复旦大学附属上海市第五人民医院内分泌科同位素室,上海200240 [3]复旦大学附属上海市第五人民医院内分泌科免疫室,上海200240 [4]复旦大学附属上海市第五人民医院内分泌科心血管超声室,上海200240

出　　处：《中华内分泌代谢杂志》2007年第4期323-324,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：检测了2型糖尿病一级亲属、单纯肥胖和健康对照者内脂素(visfatin)、内皮依赖性血管舒张功能、颈总动脉内膜中层厚度,并用MRI评价内脏脂肪和皮下脂肪面积。结果提示2型糖尿病一级亲属中肥胖患者和单纯肥胖患者内脂素水平高于2型糖尿病一级亲属非肥胖者和健康对照组,并且内脂素与空腹血糖呈独立负相关。The plasma visfatin, endothelium-dependent artery dilation and intima-media thickness of common carotid arteries were measured in first-degree relatives of type 2 diabetes, obese patients and control subjects. Regional body fat were detected by MRI. The result suggested that plasma visfatin levels were significantly higher in obese subjects than those in non-obese subjects, and hypervisfatinemia is independently associated with fasting blood glucose.

关 键 词：内脂素 糖尿病 2型 一级亲属 肥胖症 

分 类 号：R587.1[医药卫生—内分泌]