eNOS基因T-786C变异与糖尿病肾病相关  

Association of T-786C polymorphisms of eNOS gene with diabetic nephropathy

作　　者：向光大[1] 孙慧伶[1] 赵林双[1] 乐岭[1] 侯洁[1] 徐琳[1] 

机构地区：[1]广州军区武汉总医院内分泌科,湖北武汉430070

出　　处：《中华内分泌代谢杂志》2007年第4期341-342,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：湖北省卫生厅科研课题资助项目(JX2844)

摘　　要：采用PCR/ASO探针杂交技术检测早期糖尿病肾病(DN)患者、糖尿病非DN患者及健康个体血管内皮一氧化氮合酶基因5′一侧翼区T-786C变异,结果提示该位点变异与DN发生可能有关。PCR/ASO probes were applied to analyse the T-786C polymorphisms in 5＇-flanking region of endothelial nitric oxide synthase （eNOS） gene in type 2 diabetic patients with or without nephropathy and healthy individuals. The results showed that the T-786C polymorphisms of eNOS gene seemed to be related to diabetic nephropathy in type 2 diabetes.

关 键 词：糖尿病 2型 糖尿病肾病 一氧化氮合酶 多态现象 遗传 

分 类 号：R587.2[医药卫生—内分泌]