波形蛋白、NF-κB在桥本甲状腺炎中的表达  

Expressions of vimentin and NF-κB in Hashimoto′s thyroiditis

作　　者：王顿[1] 黄高昇[1] 王娟红[1] 李袁飞[1] 王文清[1] 张伟平[1] 王璐[1] 

机构地区：[1]陕西西安第四军医大学西京医院病理科,710032

出　　处：《中华内分泌代谢杂志》2007年第4期342-343,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(30470825)

摘　　要：采用免疫组织化学方法,检测波形蛋白(vimentin)、NF-κB在26例桥本甲状腺炎(HT)及9例正常甲状腺组织中的表达。结果显示桥本组中波形蛋白表达较对照组明显增强,表明HT甲状腺滤泡上皮细胞存在上皮间叶转化,而NF-κB与波形蛋白表达增加有密切关系。The expressions of vimentin and NF-κB were detected in thyroid tissue by immunohistoehemistry in 26 cases with Hashimoto＇s thyroiditis and 9 normal subjects. The results showed that there was a significantly increased expression of vimentin in Hashimoto＇s thyroiditis as compared with the normal controls. It indicated that epithelial-mesenchymal transformation existed in follicular epithelial cells of Hashimoto＇s thyroiditis. Furthermore ,the expression of vimentin was closely related with NF-κB.

关 键 词：甲状腺炎 自身免疫性 波形蛋白 NF—κB 免疫组织化学 

分 类 号：R581.4[医药卫生—内分泌]