应用2D NMR技术研究罗汉果醇及其苷的结构  

NMR Structural Elucidation of Mogrol and Its Glycosides

作　　者：杨秀伟[1] 张建业[1] 

机构地区：[1]北京大学药学院,天然药物及仿生药物国家重点实验室,北京100083

出　　处：《波谱学杂志》2007年第3期249-260,共12页Chinese Journal of Magnetic Resonance

基　　金：国家高技术研究发展863计划(2002AA2Z343C);北京市科技专项(Z0004105040311)资助项目.

摘　　要：从传统中药罗汉果中分离得到一系列三萜皂苷类化合物,其苷元为罗汉果醇,应用1D和2D NMR脉冲梯度场反相技术(gCOSY,gNOESY,gHMQC,gHMBC)研究了罗汉果醇及其苷的结构,对其碳氢NMR信号进行了全归属,应用gNOESY技术研究了罗汉果醇的立体构型,并探讨了取代基对苷元质子和碳化学位移的影响.Mogroside Ⅲ was isolated from the fruit of Momordica grosvenori Swingle [Siraitia grosvenorii （Swingle） C. Jeffery]. Mogrol （9β-methyl-19-norlanost-5-ene-3β, 11α, 24β, 25-tetrol） was derived from mogroside Ⅲ by mild enzymatic hydrolysis. Onedimensional and two-dimensional NMR （including gCOSY, gNOESY, gHSQC and gH- MBC） techniques were employed to assign the chemical shifts and elucidate the structures of the compounds. The effects of the substitutent groups on the ^1H and ^3C chemical shifts of the mogroside were also discussed.

关 键 词：核磁共振 归属 结构 2D NMR 罗汉果醇 罗汉果皂苷 罗汉果 

分 类 号：O641[理学—物理化学]